Antiviral Activities of Several Oral Traditional Chinese Medicines against Influenza Viruses
Table 3
Activities of 10 oral medicines against 5 influenza strains.
Drug
A/Fort Monmouth/1/1947
A/Jinnan/15/2009
A/Wuhan/359/1995
A/Zhuhui/1222/2010
BV/shenzhen/155/2005
IC50
SI
IC50
SI
IC50
SI
IC50
SI
IC50
SI
8.78 ± 8.17
>11.39
39.82 ± 11.24
>2.51
2.57 ± 0.09
>38.91
32.60 ± 14.64
>3.07
67.68 ± 14.05
>1.48
4.27 ± 3.14
>23.42
2.42 ± 1.13
>41.32
12.8 ± 19.5
>7.81
21.06 ± 17.36
>4.75
6.70 ± 3.25
>14.93
9.49 ± 4.89
>10.54
6.64 ± 0.68
>15.06
12.5 ± 16.6
>8.00
23.11 ± 0
>4.33
11.11 ± 0
>9.00
3.12 ± 1.92
15.41
7.37 ± 4.58
6.52
5.33 ± 2.90
9.02
21.18 ± 2.74
2.27
>25.00
—
2.21 ± 0
>45.25
5.82 ± 3.61
>17.18
9.32 ± 11.82
>10.73
19.24 ± 0
>5.20
8.57 ± 0.18
>11.67
2.81 ± 1.59
20.55
6.52 ± 1.15
8.86
1.19 ± 0.18
48.52
7.43 ± 1.44
7.77
11.11 ± 0
5.20
2.24 ± 0.60
44.64
5.30 ± 1.28
18.87
>50.00
—
15.23 ± 1.29
6.57
16.70 ± 2.11
5.99
3.77 ± 0.21
26.53
2.79 ± 1.04
35.84
8.36 ± 6.56
11.96
2.50 ± 0.75
40
5.11 ± 3.25
19.57
0.88 ± 0.26
90.91
2.48 ± 0
32.26
1.45 ± 0.17
55.17
7.52 ± 3.06
10.64
>11.11
—
2.88 ± 1.82
11.46
3.13 ± 1.83
10.54
>12.50
—
7.06 ± 0.91
4.67
2.87 ± 0
11.50
1.01 ± 0.40
>198.02
>200.00
—
0.94 ± 0.32
>212.77
1.29 ± 0.25
>155.04
91.07 ± 34.51
>2.20
0.17 ± 0.06
230.71
2.86 ± 0.91
13.71
2.86 ± 0.78
13.71
5.93 ± 0.27
6.61
>20
—
Note: L/mL; g/mL. IC50: 50% cell-inhibitory concentrations; SI: selectivity index; SI = TC50/IC50. “—”: no antiviral activity at the maximal nontoxic concentration. : each value represents the mean ± SD.
