Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Tab 3

Research Article

Effects of a Proprietary Standardized Orthosiphon stamineus Ethanolic Leaf Extract on Enhancing Memory in Sprague Dawley Rats Possibly via Blockade of Adenosine A2A Receptors

Table 3

Adenosine receptor A1 functional assay parameter.

Adenosine A1

SourceWistar rat vas deferens
Control 0.3 M CHA (N6-cyclohexyladenosine)
Vehicle0.10% DMSO
Incubation time/temp.5 minutes at 32°C
Incubation bufferKREBS pH 7.4
Quantitation method Isometric (gram changes)
Significant criteria for agonist≥50% reduction of neurogenic twitch relative to 0.3 M CHA response
Significant criteria for antagonist≥50% inhibition of 0.3 M CHA-induced relaxation

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