Mori Folium and Mori Fructus Mixture Attenuates High-Fat Diet-Induced Cognitive Deficits in Mice

Figure 4

Effect of MFE on presynaptic loss induced by high-fat diet in CA3 region of the hippocampus. The recovery effect of MFE on high-fat diet-induced synaptic dysfunction was investigated using SYN immunohistochemistry (f). Representative photomicrographs are shown for the CA3 region of each group ((a)–(e)): (a) normal groups, (b) high-fat diet group, and ((c), (d), and (e)) high-fat diet/MFE group (0.2, 0.5, and 1 g/kg/day treated, resp.). Scale bar = 200 μm. Values are expressed as the mean ± SEM ( mice per group). as compared to the normal group. ^## as compared to the high-fat diet group.

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