Research Article

Safety Evaluation of Chinese Medicine Injections with a Cell Imaging-Based Multiparametric Assay Revealed a Critical Involvement of Mitochondrial Function in Hepatotoxicity

Table 1

Phenotypic changes in subacute toxicity test.

GroupDeath/total animalsAbnormalities

Control0/6Normal
DHI high-dose 0/6Normal
DHI low-dose 0/6Normal
XDI high-dose 1/61/6 hind limb paralyzed
XDI low-dose 0/6Normal
MLNI high-dose 0/6Normal
MLNI low-dose 0/6Normal
FFKSI high-dose 2/66/6 twitched after injection
FFKSI low-dose 1/61/6 hind limb paralyzed