Gray Matter Volumes in Patients with Chronic Fatigue Syndrome

Table 2

The regions of gray matter volumes change with different factors.

Factors	Regions
Chronic pain	Cingulate cortex, prefrontal cortex, insula, and dorsal pons [55]
Personality	Orbitofrontal, occipital, and parietal structures; anterior prefrontal cortex (negatively related to women) [63]
Stress	Right orbitofrontal area of the prefrontal cortex [66–68]
Psychiatric disorder	Amygdala, hippocampal and parahippocampal, the ventral, medial temporal lobes, insular cortex [80]
Physical activity	Right prefrontal and cingulate cortex, left prefrontal cortex, cingulate cortex, bilateral occipitotemporal regions, and cerebellum, right anterior frontal cortex, middle prefrontal gyrus, anterior cingulate cortex, and supplementary motor area [83, 84]
Insomnia	Left orbitofrontal cortex, bilateral anterior precuneus of the parietal cortex, and bilateral posterior precuneus in the occipitoparietal cortex [85]