Safety of Chinese Herbal Medicine for Chronic Obstructive Pulmonary Disease

Table 3

CHM formula and ingredients of studies with adverse events in treatment groups.

CHM intervention; route of administration	Herbal ingredients	References
Bu fei jian pi or Bu fei yi shen or Yi qi zi shen, oral	Bu fei jian pi: huang qi, dang shen, bai zhu, fu ling, and chuan bei mu; Bu fei yi shen: ren shen, huang qi, gou qi zi, shan zhu yu, and yin yang huo; Yi qi zi shen: ren shen, huang jing, shu di huang, mai dong, and wu wei zi	[29]
Chen xia liu jun zi tang + San zi yang qin tang (modified), oral	Dang shen, bai zhu, fu ling, chen pi, fa xia, su zi, lai fu zi, bai jie zi, tao ren, zhe bei mu, bei xing, hai ge qiao, and gan cao	[17]
CHM formula (unnamed), oral	Ma huang, bai guo, sang bai pi, zhe bei mu, gua lou, huang qin, su zi, zi he che, and ge jie	[54]
CHM formula (unnamed), oral	Fa ban xia, fu ling, chuan xiong, chao gu ya, chao mai ya, bai he, shan yao, sha shen, fo shou, shan zha, jin fei cao, and zhe bei mu	[26]
Fei shu jiao nang, oral	Hong shen, ge jie, san qi, chuan bei mu, di long, chuan xiong, and gan cao	[56]
Fu zheng hua tan qu yu tang (modified), oral	Zhi fu zi, bu gu zi, ting li zi, chuan xiong, and yu jin	[45]
Fu zheng qing tan hua yu, oral	Sheng shai shen/ren shen, ha jie, wu wei zi, xing ren, gua lou, xie bai, dan shen, tao ren, and mao dong qing	[50]
Gu ben ke chuan pill, oral	NS	[42]
Hua zhuo qu yu tang, oral	Chi shao, dan shen, tao ren, hong hua, gua lou, su mu, zi su zi, zhe bei mu, fu ling, kuan dong hua, yu xing cao, and gan cao	[21]
Huang qi tang, oral	Huang qi, dang shen, bai zhu, gua lou, xing ren, tao ren, chuan xiong, dang gui, chen pi, and huang qin	[20]
Jian pi yi fei II (modified), oral	Dang shen, bai zhu, suo yang, and tao ren	[44]
Jin kui shen qi pill + Ma xing shi gan formula + Xiao qing long formula + Bu fei formula, oral	Jin kui shen qi pill: shu di huang, shan zhu yu, shan yao, shu fu zi, gui zhi, bu gu zhi, fu ling, tao ren, ze xie, and wu wei zi; Ma xing shi gan formula: ma huang, xing ren, huang qin, jie geng, sheng shi gao, yu xing cao, jin yin hua, lian qiao, zhe bei, tao ren, and gan cao; Xiao qing long formula: gui zhi, bai shao, gan jiang, ma huang, ban xia, zhe bei, xi xin, chuan xiong, wu wei zi, and gan cao; Bu fei formula: shu di, huang qi, dang shen, sang bai pi, zi yuan, kuan dong hua, qian hu, chen pi, wu wei zi, dan shen, su zi, and bai jie zi	[40]
Jin shui bao jiao nang, oral	Jin shui bao jiao nang	[14, 36]
Liu jun zi pill, oral	NS	[58]
Ma xing shi gan tang, oral	Ma huang, xing ren, shi gao, gan cao, lai fu zi, ting li zi, fu ling, jv hong, zhu ru, shi chang pu, yu jin, gui zhi, fu ling, bai zhu, zhu ling, and ze xie	[15]
Mai men dong tang (Bakumondoto), oral	Mai men dong, ban xia, gu ya, da zao, ren shen, and gan cao	[39]
Shen ge jiao nang, oral	Ren shen, chuan bei, zi he che, and zhi ge jie	[30]
Tan re qing, inhaled	NS	[22]
Tan re qing, IV	Huang qin, jin yin hua, lian qiao, xiong dan fen, and shan yang jiao	[18, 19, 24, 28, 33, 35, 37, 41, 46, 52]
Wen qing di tan yin (modified), oral	Jiang ban xia, bei xi xin, wu wei zi, gan jiang, ting li zi, fu ling, and wang jiang nan. If yin deficiency, add sha shen, mai dong; if phlegm heat, add sang bai pi, gua lou pi	[31]
Xi xin nao, IV	NS	[16]
Xiao ke chuan jiao nang, oral	Man shan hong	[43]
Xue bi jing, IV	NS	[38]
Yang he tang (modified), oral	Su di, su zi, rou gui, gan cao, zhi ma huang, lu jiao jiao, bai jie zi, fa xia, shu mu, chen pi, and pao jian. If with cough, add chuan bei, zhi zhi wan; if with phlegm, add gua lou ren, cao miao zi; if spleen qi deficiency, add dang shen, bai zhu; if blood stasis, add dan shen, tao ren, yi mu cao; if with heat, remove rou gui, lu jiao jiao, and su di and add sang bai pi, zhe bei, se gan, and huang qin	[59]
Yi qi qing fei tang, oral	Huang qi, dan shen, huang qin, bei mu, ban xia, jie geng, gua lou qiao, and yu xing cao	[23]
Yi xin kang tai jiao nang, oral	Tang gu te qian xian lian, duo xian xian gou zi, tang gu te da huang, and shuo yang	[55]
Yu ping feng ke li + Bai ling capsule + Jian pi yi fei chong ji, oral	Yu ping feng ke li: NS; Bai ling capsules: NS; Jian pi yi fei chong ji: ren shen, bai zhu, fu ling, mai dong, sang bai pi, and huang qi	[25]

IV: intravenous; NS: not specified.