Protective Effect of Ethanolic Extract of Grape Pomace against the Adverse Effects of Cypermethrin on Weanling Female Rats

Figure 5

Photomicrograph of kidney sections stained by haematoxylin and eosin (H&E, ×400) for histopathological changes. Group 1 showing (a) the normal histopathological structure of renal parenchyma, normal glomerulus (small arrow), and normal renal tubules (large arrow). Groups II and III (grape pomace extract at 100 and 200 mg/kg. b.wt.) showing no histopathological changes (b). Group IV (cypermethrin at 25 mg/kg. b.wt.) showing vacuolation of endothelial lining glomerular tufts (small arrow) and necrosis of epithelial lining renal tubules (large arrow) (c1), atrophy of glomerular tuft (arrow) (c2), hypertrophy of glomerular tuft (small arrow) and congestion of renal blood vessels (large arrow) (c3), and vacuolation and congestion of glomerular tufts (arrow) (c4). Group V (grape pomace extract at 100 mg/kg plus cypermethrin) showing vacuolation of endothelial lining glomerular tufts (d). Group VI (grape pomace extract at 200 mg/kg b.wt. plus cypermethrin) showing no histopathological changes (e).