Protective Effect of Ethanolic Extract of Grape Pomace against the Adverse Effects of Cypermethrin on Weanling Female Rats

Table 1

The severity of the reaction in liver and kidney according to the histopathological alteration.

Histopathological alterations	Group
	I	II	III	IV	V	VI
Liver
Kupffer cell activation	−	+	+	+++	++	+
Portal infiltration with inflammatory cells	−	−	−	++	−	−
Hyperplasia of bile duct	−	−	−	+++	−	−
Congestion of central vein and hepatic sinusoids	−	−	−	++	−	−
Kidney
Vacuolization of endothelial lining glomerular tuft	−	−	−	+++	+	−
Vacuolization of epithelial lining renal tubules	−	−	−	++	−	−
Necrosis of epithelial	−	−	−	++	−	−

Nil (−), mild (+), moderate (++), and severe (+++). Groups: control (I), grape pomace extract at 100 mg/kg b.wt. (II), grape pomace extract at 200 mg/kg b.wt. (III), cypermethrin (IV), cypermethrin and grape pomace extract at 100 mg/kg b.wt. (V), and cypermethrin and grape pomace extract at 100 mg/kg b.wt. (VI).