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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 390416, 7 pages
Research Article

Ninety-Day Oral Toxicity Assessment of an Alternative Biopolymer for Controlled Release Drug Delivery Systems Obtained from Cassava Starch Acetate

1Laboratory of Toxicology and Pharmacology of Natural Products, Paranaense University, P.O. Box 224, 87502-210 Umuarama, PR, Brazil
2Department of Pharmacology, Federal University of Paraná, P.O. Box 19031, 81531-990 Curitiba, PR, Brazil
3University Center Cesumar, P.O. Box 447, 87050-900 Maringá, PR, Brazil
4Laboratory of Cardiovascular Pharmacology, Faculty of Health Sciences, Federal University of Grande Dourados, Rodovia Dourados-Itahum, km 12, P.O. Box 533, 79.804-970 Dourados, MS, Brazil

Received 22 May 2015; Revised 25 August 2015; Accepted 30 August 2015

Academic Editor: Raffaele Capasso

Copyright © 2015 Douglas Rossi Jesus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The large consumption of biodegradable films from cassava starch acetate (FCSA) as ingredients in food and pharmaceutical products requires the assessment of the possible toxicity of these products. The aim of this study was to investigate the toxicity of biodegradable film from cassava starch acetate after oral exposure of Wistar rats for 90 days. The amount of food consumed and the body weight were weekly monitored. Blood and urine samples were obtained for the assessment of serum parameters and renal function. Histopathological analyses in target organs were also performed. No evidence of clinical toxicity in hematological, biochemical, or renal parameters in the FCSA-treated animals was found. In addition, relative organ weight and histopathological evaluations did not differ between groups treated with FCSA and control. Data obtained suggest that the subchronic exposure to FCSA does not cause obvious signs of toxicity in Wistar rats, indicating possible safety of this biofilm.