Research Article

Ninety-Day Oral Toxicity Assessment of an Alternative Biopolymer for Controlled Release Drug Delivery Systems Obtained from Cassava Starch Acetate

Table 3

Effect of FCSA on biochemical parameters of male and female Wistar rats exposed for 90 days.

ParametersControlFCSA 3 mg/kg/dayFCSA 30 mg/kg/dayFCSA 300 mg/kg/day
Male FemaleMaleFemaleMaleFemaleMaleFemale

Glucose (mg/dL)139 ± 7.4122 ± 5.1139 ± 6.0144 ± 7.1130 ± 6.0131 ± 5.1137 ± 4.9138 ± 6.2
Total cholesterol (mg/dL)59 ± 1.460 ± 3.456 ± 2.157 ± 2.559 ± 1.763 ± 3.460 ± 2.763 ± 3.0
HDL cholesterol (mg/dL)35 ± 1.136 ± 2.433 ± 1.433 ± 1.836 ± 1.138 ± 1.837 ± 1.439 ± 2.1
Triglycerides (mg/dL)54 ± 6.756 ± 3.951 ± 6.764 ± 5.848 ± 5.154 ± 4.153 ± 6.555 ± 3.3
Urea (mg/dL)36 ± 2.533 ± 3.438 ± 2.034 ± 3.441 ± 3.134 ± 2.944 ± 2.434 ± 2.8
Creatinine (mg/dL)0.47 ± 0.020.48 ± 0.040.49 ± 0.010.49 ± 0.040.49 ± 0.010.50 ± 0.030.47 ± 0.010.48 ± 0.04
Sodium (mEq/L)141 ± 1.0138 ± 1.4142 ± 1.3139 ± 1.1139 ± 0.6137 ± 1.0141 ± 1.3137 ± 0.6
Potassium (mEq/L)5.6 ± 0.16.0 ± 0.25.5 ± 0.26.0 ± 0.35.5 ± 0.15.8 ± 0.35.7 ± 0.35.6 ± 0.3
Uric acid (mg/dL)1.0 ± 0.11.2 ± 0.11.2 ± 0.21.5 ± 0.21.0 ± 0.11.4 ± 0.11.1 ± 0.21.5 ± 0.1
Total protein (g/dL)5.4 ± 0.15.4 ± 0.15.3 ± 0.15.4 ± 0.15.3 ± 0.15.5 ± 0.15.2 ± 0.15.5 ± 0.2
Albumin (g/dL) 3.5 ± 0.13.7 ± 0.13.5 ± 0.13.7 ± 0.13.5 ± 0.13.8 ± 0.13.4 ± 0.13.8 ± 0.1
Globulin (g/dL)1.9 ± 0.11.7 ± 0.11.8 ± 0.11.7 ± 0.11.8 ± 0.11.7 ± 0.11.8 ± 0.11.7 ± 0.1
Amylase (U/L)732 ± 24722 ± 76699 ± 41667 ± 58703 ± 37664 ± 67756 ± 41596 ± 59
Alkaline phosphatase (U/L)154 ± 11106 ± 9154 ± 11107 ± 15139 ± 9106 ± 4153 ± 11100 ± 7
AST (U/L)99 ± 9124 ± 6120 ± 9117 ± 798 ± 8117 ± 699 ± 10134 ± 12
ALT (U/L)49 ± 242 ± 258 ± 640 ± 250 ± 142 ± 253 ± 541 ± 2
Total bilirubin (mg/dL)0.15 ± 0.010.12 ± 0.010.17 ± 0.020.13 ± 0.010.16 ± 0.010.19 ± 0.040.15 ± 0.010.15 ± 0.01
Direct bilirubin (mg/dL)0.10 ± 0.010.07 ± 0.010.11 ± 0.020.08 ± 0.010.11 ± 0.010.10 ± 0.020.09 ± 0.020.10 ± 0.01
Indirect bilirubin (mg/dL)0.05 ± 0.010.05 ± 0.010.06 ± 0.010.05 ± 0.010.05 ± 0.010.09 ± 0.010.06 ± 0.020.05 ± 0.01

Values are expressed as mean ± S. E. M. of ten rats in each group in comparison to the control using one-way ANOVA followed by Bonferroni’s test.