Potent Antiproliferative Effect on Liver Cancer of Medicinal Plants Selected from the Thai/Lanna Medicinal Plant Recipe Database “MANOSROI III”

Table 3

Antiproliferative activity on HepG2 cell line, DPPH radical scavenging and metal chelating activities and total phenolic and flavonoid contents of 7 semipurified fractions from the HF of V. denticulata ME.

Number	Extracts of Ventilago denticulata	Hep G2					DPPH				Chelating			Phenolic content		Flavonoid content
		IC50 (µg/mL)	Folds of		NCI criteria	Rank	SC50 (µg/mL)	Folds of		Rank	CC50 (µg/mL)	Folds of	Rank	QE (µg/mg)	Rank	QE (µg/mg)	Rank
			C	D				T	A			E
1	ME	20.88	1.26	0.03	MA	3	>100	ND	ND	—	>500	ND	5	83.73	3	10.08	6
2	HF	19.30	1.37	0.03	A	2	>100	ND	ND	—	>500	ND	5	48.75	4	26.00	5
3	HF-1	>100	—	—	IA	5	>100	ND	ND	—	319.60	0.04	3	12.70	7	36.63	2
4	HF-2	6.49	4.07	0.08	A	1	>100	ND	ND	—	>500	ND	5	7.41	8	35.08	3
5	HF-3	>100	—	—	IA	5	>100	ND	ND	—	>500	ND	5	32.75	6	33.52	4
6	HF-4	59.60	0.44	0.01	MA	4	>100	ND	ND	—	158.45	0.08	1	169.99	1	556.54	1
7	HF-5	>100	—	—	IA	5	>100	ND	ND	—	216.40	0.06	2	108.97	2	ND	8
8	HF-6	>100	—	—	IA	5	>100	ND	ND	—	375.33	0.03	4	27.40	5	5.90	7
9	HF-7	>100	—	—	IA	5	>100	ND	ND	—	>500	ND	5	6.54	9	ND	8
Standard	Cisplatin (C)	26.40	1.00	—	—	—	—	—	—	—	—	—	—
	Doxorubicin (D)	0.54	—	1.00	—	—	—	—	—	—	—	—	—
	α-Tocopherol (T)	—	—	—	—	—	23.80	1.00	0.77	—	NT	ND	—
	Ascorbic acid (A)	—	—	—	—	—	18.30	1.30	1.00	—	NT	ND	—
	EDTA (E)	—	—	—	—	—	NT	ND	ND	—	12.90	1.00	—

Folds of the standard drug were calculated as the ratio between the IC₅₀ value of the standard drug and samples. NCI criteria: NCI criteria indicated three types of the activity. A: active (IC₅₀ value was less than 20 µg/mL), MA: moderately active (IC₅₀ value was between 20 and 100 µg/mL), and IA: inactive (IC₅₀ value was more than 100 µg/mL). NT: not tested, ND: not determined.
QE: quercetin equivalent.