CDRI-08 Attenuates REST/NRSF-Mediated Expression of NMDAR1 Gene in PBDE-209-Exposed Mice Brain

Figure 2

The prophylactic role of CDRI-08 (BM) (40, 80, and 120 mg/kg) against PBDE-209 (20 mg/kg) on mRNA expression of NR1 in hippocampus of male mice at neonate and young age. M: marker (1000 bp DNA ladder), −Ve: negative control. Histograms represent cumulative data expressed as mean ± SEM obtained from three different sets of experiments. , PBDE-209 versus control groups and , B. monnieri doses versus PBDE-209 groups. RDV: relative densitometric value; C: control (vehicle); P: PBDE-209 (20 mg/kg); BM40: B. monnieri (40 mg/kg); BM80: B. monnieri (80 mg/kg); BM120: B. monnieri (120 mg/kg).