Sulforaphane Reverses the Expression of Various Tumor Suppressor Genes by Targeting DNMT3B and HDAC1 in Human Cervical Cancer Cells

Table 1

Residues defining the substrate binding pocket of HDAC1 and mDNMT3B. Active site residues are underlined.

Protein	Residues lining the substrate binding cavity
mDNMT3B	C-651, E-605, F-581, D-582, G-583, T-586, S-604, E-605, V-606, C-607, V-628; G-648, S-649, P-650, C-651, N-652, S-655, V-657, N-658, P-659, L-671, E-697; V-699, V-700, A-701, R-731, A-732, R-733, R-773, I-774, K-777, S-778, N-779, S-780; I-781, R-823, G-824, Q-827, K-828, G-831, R-832, S-833, W-834
HDAC1	H-140, H-141, D-176, H-178, D-264, L-271, F-109, W-135, A-136, G-137, L-139, G-149, C-151, F-205, Zn ion