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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 418023, 5 pages
http://dx.doi.org/10.1155/2015/418023
Research Article

Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice

1Department of Gastroenterology, Tangshan Gongren Hospital, Tangshan 06300, China
2Department of Intensive Care Unit, Hebei United University Affiliated Hospital, Tangshan 06300, China
3Department of Hepatobiliary Surgery, Tangshan Gongren Hospital, Tangshan 06300, China

Received 6 July 2014; Accepted 22 July 2014

Academic Editor: John E. Smith

Copyright © 2015 Lijun Hao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We investigated the effects of Hericium erinaceus (HEM) on liver injury induced by acute alcohol administration in mice. Mice received ethanol (5 g/kg BW) by gavage every 12 hrs for a total of 3 doses. HEM (200 mg/kg BW) was gavage before ethanol administration. Subsequent serum alanine aminotransferase (ALT) level, aspartate aminotransaminase (AST) level, Maleic dialdehyde (MDA) level, hepatic total antioxidant status (TAOS), and activated nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) were determined by ELISA and immunohistochemistry, respectively. HEM administration markedly decreased serum ALT, AST, and MDA levels. The hepatic histopathological observations showed that HEM had a relatively significant role in mice model, which had alcoholic liver damage. In conclusion, we observed that HEM (200 mg/kg BW) supplementation could restrain the hepatic damage caused by acute alcohol exposure.