Molecular Signatures in the Prevention of Radiation Damage by the Synergistic Effect of N-Acetyl Cysteine and Qingre Liyan Decoction, a Traditional Chinese Medicine, Using a 3-Dimensional Cell Culture Model of Oral Mucositis

Table 2

Genes related to damage-associated molecular patterns (DAMPs) that are upregulated or downregulated in NAC, TCM or NAC-TCM pretreated human 3D-cultured oral tissues after 12 Gy irradiation.

Gene symbol	Fold change compared with nonirradiated and untreated control ()				Entrez gene	Gene description
	Untreated	NAC	TCM	NAC-TCM
S100A16	0.94	0.98	0.88	0.76^*	140576	S100 calcium-binding protein A16
S100A12	1.47^*	1.05	1.24	1.20	6283	S100 calcium-binding protein A12
S100A11	1.29^*	1.03	1.20	1.09	6282	S100 calcium-binding protein A11
RAGE (AGER)	1.10	1.18	0.77^*	0.57^*	177	Receptor of advanced glycosylation end-products
SAA1	1.32^*	1.59^*	0.89	0.87	6288	Serum amyloid A1
SAA2	1.20^*	1.23^*	1.08	1.00	6289	Serum amyloid A2
TLR2	1.10	1.07	0.79	0.70	7097	Toll-like receptor 2
IL1R2	0.36^*	0.56^*	0.53^*	0.52^*	7850	Interleukin-1 receptor, type II
IL1A	0.71^*	0.78	1.69^*	0.98	3552	Interleukin-1A

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