Research Article

The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model

Figure 1

The effect of Areca nut extract (ANE) on spatial working memory in cuprizone- (CPZ-) induced mouse demyelination model. After 1 week of acclimation, male C57BL/6 mice were fed rodent chow containing 0.2% CPZ (w/w) for 8 weeks to induce demyelination. Mice in the ANE treatment groups were fed rodent chow containing 0.2% CPZ plus 1% ANE (ANE1) or 2% ANE (ANE2). The control mice received normal rodent chow. Data were expressed as the mean ± SEM. . . . indicates comparison with the control group while # indicates comparison with the CPZ group.