Research Article

Suppression of Propionibacterium acnes-Induced Dermatitis by a Traditional Japanese Medicine, Jumihaidokuto, Modifying Macrophage Functions

Figure 1

Suppression of P. acnes-induced dermatitis in rats by jumihaidokuto administration. Dermatitis was induced by intradermal injection of heat-killed P. acnes bacteria suspended in saline (0.14 mg/50 μL/ear) into the pinna. The thickness of the ears was measured at 0, 2, 4, 6, and 24 h and 2, 3, 4, 5, 6, and 7 d after the injection. Jumihaidokuto (JHT) suspended in distilled water (DW) was given orally to rats at doses of 0.1, 0.5, 1, or 2 g/10 mL/kg, at 1 h before 6, 24 h, 2, 3, 4, 5, and 6 d after the injection. Prednisolone (PDN, 10 mg/10 mL/kg) was used as a reference drug. Data represent the relative ear thickness, which was standardized against the previous values before the injection. (a) or 6-7 (b). versus saline + DW group, , 0.01 significant versus P. acne + DW group (two-way repeated measures ANOVA + Bonferroni test).
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(b)