Liver Damage Associated with Polygonum multiflorum Thunb.: A Systematic Review of Case Reports and Case Series

Table 1

Patient details recorded from published case reports.

Reference	Age/gender	Reasons for medication	HSW type	Administration and dosage	Duration of intake, day	Hospitalization, day	Outcome	Rechallenge?
Liu et al. [42]	20/F	Grey hair	HSW	OAP, 15 g	42	10	Recovery	NA
Miao and Yun [43]	52/F	Health care	P. HSW	OAP, 5 g	20	14	Recovery	NA
	61/F	Hyperlipidemia	R. HSW	SIW, 5 g	180	12	Recovery	NA
Zhao [44]	39/M	Grey hair	Jing-Wu-Pian	Oral, 3 × 6 tablets	60	18	Recovery	NA
Tan [45]	48/F	NA	P. HSW	uNA, 10 g	40	30	Recovery	NA
Liu et al. [46]	37/M	Vitiligo	P. HSW	OAP, 10 g	30	35	Recovery	NA
Gao et al. [47]	14/F	Vitiligo	P. HSW	Decoction, NA	38	15	Recovery	NA
Baňárová et al. [48]	33/F	NA	SWW	Oral, NA	60	NA	Recovery	NA
Gao [49]	45/M	Hair loss	P. HSW	OAP, NA	90	21	Recovery	NA
Kui and Chen [50]	43/F	Grey hair	HSW	OAP, 8–10 g	60	30	Recovery	NA
Shao and Li [51]	50/M	Grey hair	HSW	OAP, NA	60	30	Recovery	NA
	40/F	Health care	R. HSW	Decoction, 10–20 g	60	50	Recovery	NA
Hu et al. [52]	36/M	Chronic nephritis	P. HSW	OAP, 15 g	30	37	Recovery	NA
Zhen and Zeng [53]	52/F	Grey hair	P. HSW	OAP, NA	14	30	Recovery	NA
Li and Zhang [54]	50/F	Grey hair	R. HSW	OAP, 2 g	60	15	Recovery	NA
	28/F	Hair loss	R. HSW	OAP, 3 g	75	12	Recovery	NA
Chen et al. [55]	57/M	Grey hair	R. HSW	NA	1	20	Recovery	NA
Liu et al. [56]	56/F	Grey hair	Yishen wufa	Oral, 2 × 10 mL	120	21	Recovery	NA
Sun [57]	39/F	Allergic rhinitis	R. HSW	Decoction, 15–20 g	30	28	Recovery	NA
	72/F	Health care	R. HSW	Decoction, 10–20 g	60	42	Recovery	NA
Cao et al. [58]	28/M	Grey hair	P. HSW	NA, 10 pieces	90	42	Recovery	NA
Liu et al. [59]	26/M	Hair loss	Yangxue shengfa	Oral, 2 × 4 capsules	60	30	Recovery	NA
Yan [60]	28/M	Hair loss	HSW	Decoction, 4 g	90	28	Recovery	NA
Wu and Niu [61]	47/F	Hair loss	Yishen wufa	Oral, 3 × 10 ml	20	14	Recovery	NA
Liu et al. [62]	50/F	Hair loss	SWW	Oral, NA	7	25	Recovery	NA
Chen et al. [63]	46/F	Health care	HSW tea	Oral, 1-2 g	60	25	Recovery	NA
	57/M	Health care	HSW tea	Oral, 1-2 g	20	15	Recovery	NA
Yun et al. [64]	51/F	Grey hair	SWW	Oral, 2 × 6 g	180	18	Recovery	NA
Furukawa et al. [65]	53/F	NA	SWP	NA	240	60	Recovery	NA
Yan et al. [66]	54/F	Grey hair	HSW	OAP, 2 × 10 g	60	35	Recovery	NA
He [67]	31/F	Constipation	HSW	Oral, NA	15	10	Recovery	NA
Chen [68]	38/F	Grey hair	HSW	OAP, NA	120	63	Recovery	NA
Cho et al. [69]	34/M	NA	HSW	HSW tea (liquor), NA	30 (4)	34	improved	NA
Wang et al. [70]	34/M	Health care	R. HSW	SIW, NA	20	20	Recovery	NA
	46/M	Health care	R. HSW	SIW, NA	10	27	Recovery	NA
	49/F	Health care	R. HSW	SIW, NA	5	27	Recovery	NA
Zhu [71]	36/M	Hair loss	R. HSW	SIW, NA	30	30	Recovery	NA
Yang and Li [72]	38/M	Grey hair	HSW	Decoction, 30 g	Once a week (3w)	NA	Recovery	NA
	51/M	Sequelae of stroke	HSW	Decoction, 15 g	15	NA	Recovery	NA
Laird et al. [73]	35/M	Thinning hair	NuHair	Oral, NA	NA	120	Recovery	NA
Yang and Dong [74]	54/M	Hair loss	SWP	Oral, 3 × 6 tablets	40	17	Recovery	NA
	26/M	Grey hair	SWP	Oral, 3 × 6 tablets	30	59	Recovery	Yes
Fu and Yu [75]	32/F	Infertility	P. HSW	Decoction, NA	18	Untreated	Recovery	NA
Zhao [76]	17/M	Grey hair	SWW	Oral, 3 × 6 tablets	40	90	Recovery	Yes
Li [77]	65/M	Dizziness, tinnitus	HSW	SIW, 30–50 ml	20	30	Recovery	Yes
	38/M	Grey hair	SWP	Oral, 3 × 6 tablets	30	20	Recovery	NA
Cárdenas et al. [78]	28/F	Hair loss	Shen-Min	Oral, 2 tablets	56	6	Recovery	NA
Han [79]	42/F	Grey hair	HSW	OAP, 10 g	90	30	Recovery	Yes
Yang [80]	35/M	Grey hair	P. HSW	Decoction, 30 g	45	50	Recovery	NA
Panis et al. [81]	5/F	NA	SWP	Oral, 3 tablets	120	30	Recovery	Yes
Chen et al. [82]	20/F	Grey hair	HSW	OAP, NA	20	40	Recovery	NA
Huo and Ling [83]	28/M	Hair loss	SWP + Yangxue shengfa	Oral, 3 × 5 tablets and 2 × 4 capsules	60	18	Recovery	Yes
Mazzanti et al. [84]	78/M	Chronic prostatitis	SWP	Oral, RD	30	NA	Recovery	NA
Shao [85]	46/F	Hair loss	R. HSW	Decoction, NA	6	30	Recovery	Yes
	45/M	Grey hair, hair loss	R. HSW	Decoction, 100 g	NA	30	Recovery	Yes
Leng [32]	15/F	Grey hair	HSW	Decoction, 15 g	30	NA	Recovery	NA
Dai and Li [86]	18/F	Grey hair	SWP	Oral, NA	90	90	Recovery	NA
Yuan [87]	66/F	Constipation	HSW ointment	Oral, NA	7	30	Recovery	Yes
Sun [88]	20/F	Neurasthenia	SWP + Liuwei Dihuang Wan	Oral, 3 × 6 tablets and 2 × 9 g	3	10	Recovery	Yes
Yang [89]	17/M	Grey hair	SWP	Oral, NA	14	29	Recovery	Yes
Park et al. [90]	46/F	Grey hair	SWP	Oral, RD	14	30	Recovery	NA
Sheng [33]	38/F	Grey hair	HSW	Oral, NA	6	NA	Recovery	Yes
Li et al. [91]	58/F	Dizziness	HSW	Decoction, 30 g	7	15	Recovery	Yes
	49/M	Hypertension	HSW	SIW, 15 g	10	20	Recovery	Yes
Fan and Zhou [92]	26/M	Grey hair	SWP	Oral, 3 × 6 tablets	30	59	Recovery	Yes
Li [93]	17/M	Grey hair	SWP	Oral, 3 × 5 tablets	20	60	Recovery	Yes
Ye [34]	30/M	Grey hair	HSW	Decoction, 50 g	2	94	Recovery	Yes
Zhang [94]	36/F	NA	SWP	Oral, 10 ml	15	15	Recovery	Yes
Niu [95]	28/M	Grey hair	SWP	Oral, 3 × 5 tablets	10	60	Recovery	Yes
He and Zhen [96]	19/F	Grey hair	SWP	Oral, NA	NA	30	Recovery	Yes
	27/F	Grey hair	SWP	Oral, NA	NA	NA	Recovery	Yes
But et al. [97]	31, F	Dizziness	SWP	Oral, RD	Several weeks	21	Recovery	Yes

SWP: Shou-Wu-Pian; SWW: Shou-Wu-Wan; OAP: oral administration of powder; SIW: soaked in water to drink; P. HSW: processed HSW; R. HSW: raw HSW; HSW: unclear whether it was processed; RD: recommended dosages; NA: not available.