Pharmacological Basis for Traditional Use of the Lippia thymoides

Table 3

Antimicrobial activity of the crude extracts and fractions from leaves and stems of L. thymoides.

Sample	Microorganisms (MIC e MMC em mg/mL)
	E. coli		S. aureus		S. aureus		S. choleraesuis		B. cereus		M. luteus		C. albicans		C. parapsilosis
	CCMB 261		CCMB 262		CCMB 263		CCMB 281		CCMB 282		CCMB 283		CCMB 286		CCMB 288
	MIC	MMC	MIC	MMC	MIC	MMC	MIC	MMC	MIC	MMC	MIC	MMC	MIC	MMC	MIC	MMC
TF	5.04	5.04	5.04	5.04	5.04	5.04	5.04	9.94	4.97	4.97	5.04	5.04	9.94	9.94	4.97	4.97
TFH	5.55	<11.1	1.39	2.77	2.77	2.77	5.55	11.1	2.77	2.77	5.55	<11.1	9.94	9.94	2.48	4.97
TFD	2.77	5.55	0.35	0.69	0.17	1.39	2.77	5.55	0.17	0.17	0.69	<11.1	2.48	4.97	0.62	1.28
TFA	2.77	2.77	0.35	0.69	0.35	0.69	1.39	1.39	0.69	0.69	0.69	<11.1	4.47	9.94	4.97	9.94
TC	2.56	5.12	0.62	2.56	2.56	5.12	2.56	2.48	2.48	2.48	2.56	5.12	<9.94	<9.94	9.94	9.94
TCH	2.77	11.1	2.77	5.55	2.77	5.55	5.55	11.1	2.77	2.77	2.77	<11.1	9.94	9.94	2.48	4.97
TCD	2.77	5.55	0.35	0.69	0.69	1.39	2.77	2.77	0.69	0.69	0.69	1.39	9.94	9.94	4.97	9.94
TCA	5.00	10.00	0.31	1.25	0.62	1.25	1.28	2.48	0.62	1.28	1.25	1.25	9.94	4.97	4.97	4.97
CLO	0.675	—	0.003	—	0.084	—	0.005	—	0.005	—	0.003	—	NT	—	NT	—
NIS	NT		NT		NT		NT		NT		NT		1.25	—	2.50	—
DMSO	5.55	—	5.55	—	11.1	—	5.55	—	5.55	—	5.55	—	NT	—	NT	—

MIC, minimum inhibitory concentration; MMC, minimum microbicidal concentration; NT, nontested; TF, crude methanolic extract from leaves; TFH, hexane fraction from TF; TFD, dichloromethane fraction from TF; TFA, ethyl acetate fraction from TF; TC, crude methanolic extract from stems; TCH, hexane fraction from TC; TCD, dichloromethane fraction from TC; TCA, ethyl acetate fraction from TC; CLO, chloramphenicol; NIS, nystatin.