Renoprotective Effects of Vitex megapotamica (Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet

Figure 2

Effects of the treatment with methanolic extract of Vitex megapotamica (MEVM) on systolic blood pressure of C57BL6 LDLr-null mice. Groups of mice () were treated for 5 weeks with commercial atherogenic diet. At the end of the second week the animals received varying doses of MEVM (30–300 mg/kg) or simvastatin (40 mg/kg) for three more weeks. Systolic blood pressure measurements were carried out on a weekly basis from the beginning of experiments for 5 weeks. Each bar represents the mean and the vertical lines show the SEM. denotes significance levels compared to the beginning of the experiments (outset). Two-way ANOVA followed by Bonferroni test ().