Renoprotective Effects of Vitex megapotamica (Spreng.) Moldenke in C57BL/6 LDLr-Null Mice Undergoing High Fat Diet

Figure 4

HEVM-treatment prevents the reduction of renal excretion of chloride (a) and potassium (b) in C57BL6 LDLr-null mice. Groups of mice () were treated for 5 weeks with commercial atherogenic diet. At the end of the second week the animals received varying doses of MEVM (30–300 mg/kg) or simvastatin (40 mg/kg) for three more weeks. Electrolytes excretion was determined out on a weekly basis from the beginning of experiments for 5 weeks. Each bar represents the mean and the vertical lines show the SEM. denotes significance levels compared to the outset of experiments. Two-way ANOVA followed by Bonferroni test ().

(a)

(b)