Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Tab 2

Research Article

Ozone Therapy in the Management of Persistent Radiation-Induced Rectal Bleeding in Prostate Cancer Patients

Table 2

Rectal hemorrhage grading according to CTCAE.

GradeCriteriaBefore O3TEnd O3TLast follow-up

0No symptoms057
1Mild; intervention not indicated075
2Moderate symptoms; medical intervention or minor cauterization indicated200
3Transfusion, radiologic, endoscopic, or elective operative intervention indicated700
4Life-threatening consequences; urgent intervention indicated300

Note: CTCAE toxicity grade was significantly decreased at the end of O3T () and at the last follow-up () compared to that before O3T. Overall, the change in CTCAE toxicity grade was statistically significant ().
According to the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) grading system (version 4.0): available from http://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf.