Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 504567, 11 pages
http://dx.doi.org/10.1155/2015/504567
Research Article

Protective Effects of Salidroside on Mitochondrial Functions against Exertional Heat Stroke-Induced Organ Damage in the Rat

1Department of Emergency, The Second Military Medical University Affiliated Fuzhou General Hospital, Fuzhou, Fujian 350025, China
2Department of Emergency, Fuzhou General Hospital, Fuzhou, Fujian 350025, China
3Medical Department, Fuzhou General Hospital, Fuzhou 350025, China
4Emergency Department, Shanghai Changzheng Hospital, Shanghai 200003, China

Received 4 May 2015; Revised 5 July 2015; Accepted 22 July 2015

Academic Editor: Shuang-En Chuang

Copyright © 2015 Wei Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. M. S. Raj, A. Alladin, B. Pfeiffer et al., “Therapeutic plasma exchange in the treatment of exertional heat stroke and multiorgan failure,” Pediatric Nephrology, vol. 28, no. 6, pp. 971–974, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. P. A. Ruell, D. Simar, J. D. Périard, S. Best, C. Caillaud, and M. W. Thompson, “Lymphocyte and monocyte Hsp72 responses to exercise in athletes with prior exertional heat illness,” International Journal of Exercise Science: Conference Proceedings, vol. 10, no. 1, article 62, 2013. View at Google Scholar
  3. S.-H. Chen, M.-T. Lin, and C.-P. Chang, “Ischemic and oxidative damage to the hypothalamus may be responsible for heat stroke,” Current Neuropharmacology, vol. 11, no. 2, pp. 129–140, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Y. Li, Y. T. Qi, H. Liu et al., “Acute high-altitude hypoxic brain injury: identification of ten differential proteins,” Neural Regeneration Research, vol. 8, no. 31, pp. 2932–2941, 2013. View at Publisher · View at Google Scholar · View at Scopus
  5. M.-C. Xu, H.-M. Shi, X.-F. Gao, and H. Wang, “Salidroside attenuates myocardial ischemia-reperfusion injury via PI3K/Akt signaling pathway,” Journal of Asian Natural Products Research, vol. 15, no. 3, pp. 244–252, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Zhong, H. Xin, L.-X. Wu, and Y.-N. Zhu, “Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway,” Journal of Pharmacological Sciences, vol. 114, no. 4, pp. 399–408, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. M.-C. Xu, H.-M. Shi, H. Wang, and X.-F. Gao, “Salidroside protects against hydrogen peroxide-induced injury in HUVECs via the regulation of REDD1 and mTOR activation,” Molecular Medicine Reports, vol. 8, no. 1, pp. 147–153, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Yu, L. Liu, T. Wen et al., “Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of salidroside in rat plasma: application to the pharmacokinetics study,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 861, no. 1, pp. 10–15, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Yu, Y. Shi, X. Wei et al., “Depletion of mitochondrial DNA by ethidium bromide treatment inhibits the proliferation and tumorigenesis of T47D human breast cancer cells,” Toxicology Letters, vol. 170, no. 1, pp. 83–93, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. A. M. Falchi, V. Sogos, F. Saba, M. Piras, T. Congiu, and M. Piludu, “Astrocytes shed large membrane vesicles that contain mitochondria, lipid droplets and ATP,” Histochemistry and Cell Biology, vol. 139, no. 2, pp. 221–231, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Suzuki, H. Hasegawa, T. Tsuji et al., “Relationships of diverse apoptotic death process patterns to mitochondrial membrane potential (Δψm) evaluated by three-parameter flow cytometric analysis,” Cytotechnology, vol. 65, no. 1, pp. 59–70, 2013. View at Publisher · View at Google Scholar
  12. A. D. Martin, A.-M. Joseph, T. M. Beaver et al., “Effect of intermittent phrenic nerve stimulation during cardiothoracic surgery on mitochondrial respiration in the human diaphragm,” Critical Care Medicine, vol. 42, no. 2, pp. e152–e156, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. A. M. Petrov, A. A. Yakovleva, and A. L. Zefirov, “Role of membrane cholesterol in spontaneous exocytosis at frog neuromuscular synapses: ROS—calcium interplay,” The Journal of Physiology, vol. 593, no. 2, pp. 4995–4500, 2014. View at Google Scholar
  14. A. Partyka, E. Łukaszewicz, and W. Nizański, “Effect of cryopreservation on sperm parameters, lipid peroxidation and antioxidant enzymes activity in fowl semen,” Theriogenology, vol. 77, no. 8, pp. 1497–1504, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. A. A. Romanovsky and C. M. Blatteis, “Heat stroke: opioid-mediated mechanisms,” Journal of Applied Physiology, vol. 81, no. 6, pp. 2565–2570, 1996. View at Google Scholar · View at Scopus
  16. C. Villeneuve, C. Guilbeau-Frugier, P. Sicard et al., “P53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-a upregulation: role in chronic left ventricular dysfunction in mice,” Antioxidants and Redox Signaling, vol. 18, no. 1, pp. 5–18, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. L. R. Leon and B. G. Helwig, “Heat stroke: role of the systemic inflammatory response,” Journal of Applied Physiology, vol. 109, no. 6, pp. 1980–1988, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Qin, S. Zhou, Y. Xiao, and L. Chen, “Erythropoietin enhances mitochondrial biogenesis in cardiomyocytes exposed to chronic hypoxia through Akt/eNOS signalling pathway,” Cell Biology International, vol. 38, no. 3, pp. 335–342, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. V. N. Kotiadis, M. R. Duchen, and L. D. Osellame, “Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health,” Biochimica et Biophysica Acta, vol. 1840, no. 4, pp. 1254–1265, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Aghaei, F. Karami-Tehrani, M. Panjehpour, S. Salami, and F. Fallahian, “Adenosine induces cell-cycle arrest and apoptosis in androgen-dependent and-independent prostate cancer cell lines, LNcap-FGC-10, DU-145, and PC3,” Prostate, vol. 72, no. 4, pp. 361–375, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. L. M. T. Canzoniero, A. Granzotto, D. M. Turetsky, D. W. Choi, L. L. Dugan, and S. L. Sensi, “nNOS(+) striatal neurons, a subpopulation spared in Huntington's Disease, possess functional NMDA receptors but fail to generate mitochondrial ROS in response to an excitotoxic challenge,” Frontiers in Physiology, vol. 4, artilce 112, Article ID Article 112, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Kastl, S. W. Sauer, T. Ruppert et al., “TNF-alpha mediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-kappaB activation in liver cells,” FEBS Letters, vol. 588, no. 1, pp. 175–183, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. S. K. Farahmand, F. Samini, M. Samini, and S. Samarghandian, “Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver,” Biogerontology, vol. 14, no. 1, pp. 63–71, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Johri, A. Chandra, and M. F. Beal, “PGC-1α, mitochondrial dysfunction, and Huntington's disease,” Free Radical Biology and Medicine, vol. 62, pp. 37–46, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Candas and J. J. Li, “MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx,” Antioxidants & Redox Signaling, vol. 20, no. 10, pp. 1599–1617, 2014. View at Publisher · View at Google Scholar · View at Scopus