Hepatoprotective Effect of Terminalia chebula against t-BHP-Induced Acute Liver Injury in C57/BL6 Mice
Antioxidant enzyme and proinflammatory and anti-inflammatory-related genes expression in hepatic tissue. The mice were administered with TCW (50, 100, and 200 mg/kg), gallic acid, or distilled water orally once per day for 5 days. After 18 h of t-BHP injection, livers were removed and mRNA levels of GSH-Sy, GSH-Px, GSH-Rd, SOD-1, SOD-2, and SOD-3 (a) and CAT, iNOS, TNF-α, IL-1β, IL-6, and CYP2E1 (b) in hepatic tissue were determined using real-time PCR. The mRNA levels were normalized to that of β-actin. Data are expressed as the mean ± SD (). #, ##, and ### compared with the naive group; *, **, and *** compared with the control group.