Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 542026, 8 pages
http://dx.doi.org/10.1155/2015/542026
Research Article

Vitis vinifera (Muscat Variety) Seed Ethanolic Extract Preserves Activity Levels of Enzymes and Histology of the Liver in Adult Male Rats with Diabetes

1Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
2Pharmacology Division, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh 530 003, India
3Department of Zoology, Sri Venkateswara University, Tirupati, Andhra Pradesh 517502, India
4Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 18 June 2014; Accepted 14 August 2014

Academic Editor: Pasupuleti Visweswara Rao

Copyright © 2015 Nelli Giribabu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Sundaram, R. Naresh, P. Shanthi, and P. Sachdanandam, “Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats,” Phytomedicine, vol. 20, no. 7, pp. 577–584, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. T. Devlin, Textbook of Biochemistry with Clinical Correlations, Wiley-Liss, 5th edition, 2001.
  3. J. Berg, J. L. Tymoczko, and L. Stryer, Biochemistry, Freeman, New York, NY, USA, 7th edition, 2010.
  4. S. Y. Lunt and M. G. V. Heiden, “Aerobic glycolysis: meeting the metabolic requirements of cell proliferation,” Annual Review of Cell and Developmental Biology, vol. 27, no. 1, pp. 441–464, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. N. H. Ugochukwu and N. E. Babady, “Antihyperglycemic effect of aqueous and ethanolic extracts of Gongronema latifolium leaves on glucose and glycogen metabolism in livers of normal and streptozotocin-induced diabetic rats,” Life Sciences, vol. 73, no. 15, pp. 1925–1938, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. T. H. Lee, W. R. Kim, and J. J. Poterucha, “Evaluation of elevated liver enzymes,” Clinics in Liver Disease, vol. 16, no. 2, pp. 183–198, 2012. View at Publisher · View at Google Scholar
  7. A. N. Lucchesi, N. T. de Freitas, L. L. Cassettari, S. F. G. Marques, and C. T. Spadella, “Diabetes mellitus triggers oxidative stress in the liver of alloxan-treated rats: a mechanism for diabetic chronic liver disease,” Acta Cirurgica Brasileira, vol. 28, no. 7, pp. 502–508, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Ghouri, D. Preiss, and N. Sattar, “Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease: a narrative review and clinical perspective of prospective data,” Hepatology, vol. 52, no. 3, pp. 1156–1161, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. E. H. Harris, “Elevated liver function tests in type 2 diabetes,” Clinical Diabetes, vol. 23, no. 3, pp. 115–119, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. D. Shanmuganayagam, M. R. Beahm, M. A. Kuhns, C. G. Krueger, J. D. Reed, and J. D. Folts, “Differential effects of grape (Vitis vinifera) skin polyphenolics on human platelet aggregation and low-density lipoprotein oxidation,” Journal of Agricultural and Food Chemistry, vol. 60, no. 23, pp. 5787–5794, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. N. Orhan, M. Aslan, D. D. Orhan, F. Ergun, and E. Yeşilada, “In-vivo assessment of antidiabetic and antioxidant activities of grapevine leaves (Vitis vinifera) in diabetic rats,” Journal of Ethnopharmacology, vol. 108, no. 2, pp. 280–286, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. D. A. Oliveira, A. A. Salvador, A. Smânia, E. F. A. Smânia, M. Maraschin, and S. R. S. Ferreira, “Antimicrobial activity and composition profile of grape (Vitis vinifera) pomace extracts obtained by supercritical fluids,” Journal of Biotechnology, vol. 164, no. 3, pp. 423–432, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Sharma, A. K. Tyagi, R. P. Singh, D. C. F. Chan, and R. Agarwal, “Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells,” Breast Cancer Research and Treatment, vol. 85, no. 1, pp. 1–12, 2004. View at Publisher · View at Google Scholar
  14. S. K. Sharma, Suman, and N. Vasudeva, “Hepatoprotective activity of Vitis vinifera root extract against carbon tetrachloride-induced liver damage in rats,” Acta Poloniae Pharmaceutica, vol. 69, no. 5, pp. 933–937, 2012. View at Google Scholar · View at Scopus
  15. R. N. Andhare, M. K. Raut, and S. R. Naik, “Evaluation of antiallergic and anti-anaphylactic activity of ethanolic extract of Sanseveiria trifasciata leaves (EEST) in rodents,” Journal of Ethnopharmacology, vol. 142, no. 3, pp. 627–633, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. J. B. Harborne, Phytochemical Methods, vol. 278, Springer, 1984.
  17. OECD (Organisation for Economic and Cultural Development), “Guidelines for testing chemicals,” in Acute Oral Toxicit up and down Procedure, vol. 425, pp. 1–26, 2001. View at Google Scholar
  18. G. B. Nelli, K. Anand Solomon, and E. K. Kilari, “Antidiabetic effect of α-mangostin and its protective role in sexual dysfunction of streptozotocin induced diabetic male rats,” Systems Biology in Reproductive Medicine, vol. 59, no. 6, pp. 319–328, 2013. View at Publisher · View at Google Scholar
  19. P. Subash-Babu, A. A. Alshatwi, and S. Ignacimuthu, “Beneficial antioxidative and antiperoxidative effect of cinnamaldehyde protect streptozotocin-induced pancreatic β-cells damage in wistar rats,” Biomolecules & Therapeutics, vol. 22, no. 1, p. 47, 2014. View at Google Scholar
  20. T. H. Wright and K. E. Ferslew, “Biotransformation of ethanol to ethyl glucuronide in a rat model after a single high oral dosage,” Alcohol, vol. 46, no. 2, pp. 159–164, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. I. A. Trounce, Y. L. Kim, A. S. Jun, and D. C. Wallace, “Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines,” in Methods in Enzymology, A. C. Giuseppe and M. Attardi, Eds., pp. 484–509, Academic Press, 1996. View at Google Scholar
  22. T. Srikantan and C. Krishnamurti, “Tetrazolium test for dehydrogenases,” Journal of Scientific and Industrial Research, vol. 14, p. 206, 1955. View at Google Scholar
  23. A. Kornberg and W. E. Pricer, “Di-and triphosphopyridine nucleotide isocitric dehydrogenases in yeast,” The Journal of Biological Chemistry, vol. 189, no. 1, pp. 123–136, 1951. View at Google Scholar · View at Scopus
  24. M. M. Nachlas, S. I. Margulies, and A. M. Seligman, “A colorimetric method for the estimation of succinic dehydrogenase activity,” The Journal of Biological Chemistry, vol. 235, no. 2, pp. 499–503, 1960. View at Google Scholar · View at Scopus
  25. H. U. Bergmeyer and E. Bernt, “Glucose-6-phosphate dehydrogenase,” in Methods of Enzymatic Analysis, H. U. Bergmeyer, Ed., Academic Press, New York, NY, USA, 1965. View at Google Scholar
  26. A. Guven, O. Yavuz, M. Cam et al., “Effects of melatonin on streptozotocin-induced diabetic liver injury in rats,” Acta Histochemica, vol. 108, no. 2, pp. 85–93, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Esterbauer and K. H. Cheeseman, “Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal,” in Methods in Enzymology, A. N. G. Lester Packer, Ed., pp. 407–421, Academic Press, 1990. View at Google Scholar
  28. P. Manna, J. Das, J. Ghosh, and P. C. Sil, “Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs, and mitochondria-dependent pathways: prophylactic role of arjunolic acid,” Free Radical Biology & Medicine, vol. 48, no. 11, pp. 1465–1484, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. P. V. Rao, K. Madhavi, M. D. Naidu, and S. H. Gan, “Rhinacanthus nasutus ameliorates cytosolic and mitochondrial enzyme levels in Streptozotocin-induced diabetic rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 486047, 6 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. S. N. Singh, P. Vats, S. Suri et al., “Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats,” Journal of Ethnopharmacology, vol. 76, no. 3, pp. 269–277, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. S. R. Reddy, T. Lavany, G. Narasimhulu, and K. S. Reddy, “Effect of Pimpinella tirupatiensison oxidative enzymes in STZ-induced diabetic rat kidney,” Iranian Journal of Pharmaceutical Research, vol. 11, no. 1, pp. 277–286, 2012. View at Google Scholar · View at Scopus
  32. M. Farswan, P. M. Mazumder, and V. Percha, “Protective effect of Cassia glauca Linn. on the serum glucose and hepatic enzymes level in streptozotocin induced NIDDM in rats,” Indian Journal of Pharmacology, vol. 41, no. 1, pp. 19–22, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. E. K. Ainscow, C. Zhao, and G. A. Rutter, “Acute overexpression of lactate dehydrogenase-A perturbs β-cell mitochondrial metasbolism and insulin secretion,” Diabetes, vol. 49, no. 7, pp. 1149–1155, 2000. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Ramalingam and S.-J. Kim, “The role of insulin against hydrogen peroxide-induced oxidative damages in differentiated SH-SY5Y cells,” Journal of Receptors and Signal Transduction, vol. 34, no. 3, pp. 212–220, 2014. View at Publisher · View at Google Scholar
  35. K. Rasineni, R. Bellamkonda, S. R. Singareddy, and S. Desireddy, “Antihyperglycemic activity of Catharanthus roseus leaf powder in streptozotocin-induced diabetic rats,” Pharmacognosy Research, vol. 2, no. 3, pp. 195–201, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. A. T. Eprintsev, M. Y. Shevchenko, and V. N. Popov, “Carbohydrate metabolism in the liver of rats in food deprivation and experimental diabetes,” Biology Bulletin, vol. 35, no. 1, pp. 99–101, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. N. N. Ulusu, M. Sahilli, A. Avci et al., “Pentose phosphate pathway, glutathione-dependent enzymes and antioxidant defense during oxidative stress in diabetic rodent brain and peripheral organs: effects of stobadine and vitamin E,” Neurochemical Research, vol. 28, no. 6, pp. 815–823, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. D. Xourafas, A. Ardestani, S. W. Ashley, and A. Tavakkoli, “Impact of weight-loss surgery and diabetes status on serum ALT levels,” Obesity Surgery, vol. 22, no. 10, pp. 1540–1547, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. F. Masjedi, A. Gol, and S. Dabiri, “Preventive effect of garlic (Allium sativum L .) on serum biochemical factors and histopathology of pancreas and liver in streptozotocin-induced diabetic rats,” Iranian Journal of Pharmaceutical Research, vol. 12, no. 3, p. 325, 2013. View at Google Scholar
  40. G. Kumar, A. G. Murugesan, and M. R. Pandian, “Effect of Helicteres isora bark extract on blood glucose and hepatic enzymes in experimental diabetes,” Pharmazie, vol. 61, no. 4, pp. 353–355, 2006. View at Google Scholar · View at Scopus
  41. K. Mnafgui, “Inhibition of key enzymes related to diabetes and hypertension by Eugenol in vitro and in alloxan-induced diabetic rats,” Archives of Physiology and Biochemistry, vol. 119, no. 5, pp. 225–233, 2013. View at Google Scholar
  42. I. C. Chis, M. I. Ungureanu, A. Marton et al., “Antioxidant effects of a grape seed extract in a rat model of diabetes mellitus,” Diabetes and Vascular Disease Research, vol. 6, no. 3, pp. 200–204, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Weidner, A. Rybarczyk, M. Karamać et al., “Differences in the phenolic composition and antioxidant properties between Vitis coignetiae and Vitis vinifera seeds extracts,” Molecules, vol. 18, no. 3, pp. 3410–3426, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. S. P. Wolff, “Diabetes mellitus and free radicals. Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications,” British Medical Bulletin, vol. 49, no. 3, pp. 642–652, 1993. View at Google Scholar · View at Scopus