Research Article

Traditional Chinese Medicine Decreases the Stroke Risk of Systemic Corticosteroid Treatment in Dermatitis: A Nationwide Population-Based Study

Table 2

Cox model measured hazard ratio and 95% confidence intervals of stroke associated with dermatitis and covariates.

CharacteristicsCrudeAdjusted
HR (95% CI) valueHR (95% CI) value

Dermatitis (ref = no)
 Yes1.27 (1.23–1.3)<0.00011.13 (1.10–1.16)<0.0001
Gender (ref = male)
 Female0.67 (0.66–0.69)<0.00010.79 (0.77–0.81)<0.0001
Age, years (ref = 20–39)
 40–494.18 (3.97–4.41)<0.00013.75 (3.56–3.96)<0.0001
 50–599.58 (9.1–10.08)<0.00017.27 (6.90–7.67)<0.0001
 ≥6025.70 (24.54–26.92)<0.000116.17 (15.37–17.00)<0.0001
Comorbidity
 Asthma (ref = no)
  Yes2.42 (2.32–2.53)<0.00011.07 (1.03–1.12)0.0019
 Allergic rhinitis (ref = no)
  Yes1.02 (0.97–1.06)0.46940.95 (0.91–0.99)0.0158
 Urticaria (ref = no)
  Yes1.12 (1.07–1.17)<0.00010.99 (0.94–1.04)0.6715
 DM (ref = no)
  Yes4.20 (4.07–4.33)<0.00011.35 (1.30–1.39)<0.0001
 Hypertension (ref = no)
  Yes6.26 (6.1–6.43)<0.00011.87 (1.82–1.93)<0.0001
 Hyperlipidemia (ref = no)
  Yes3.08 (2.97–3.18)<0.00011.00 (0.96–1.04)0.9719
 AF (ref = no)
  Yes7.04 (6.28–7.9)<0.00011.68 (1.50–1.89)<0.0001
Treatment (ref = non-TCM and nonsystemic steroid)
 Only TCM0.98 (0.90–1.06)0.58711.22 (1.13–1.32)<0.0001
 Only systemic steroid2.19 (2.03–2.36)<0.00011.55 (1.43–1.67)<0.0001
 TCM and systemic steroid1.66 (1.55–1.77)<0.00011.64 (1.53–1.76)<0.0001

HR: hazard ratio; CI: confidence interval.
Adjusted HR: adjusted for age, gender, treatment, and comorbidity in Cox proportional hazards regression.