Research Article
Traditional Chinese Medicine Decreases the Stroke Risk of Systemic Corticosteroid Treatment in Dermatitis: A Nationwide Population-Based Study
Table 2
Cox model measured hazard ratio and 95% confidence intervals of stroke associated with dermatitis and covariates.
| Characteristics | Crude | Adjusted | HR | (95% CI) | value | HR | (95% CI) | value |
| Dermatitis (ref = no) | | | | | | | Yes | 1.27 | (1.23–1.3) | <0.0001 | 1.13 | (1.10–1.16) | <0.0001 | Gender (ref = male) | | | | | | | Female | 0.67 | (0.66–0.69) | <0.0001 | 0.79 | (0.77–0.81) | <0.0001 | Age, years (ref = 20–39) | | | | | | | 40–49 | 4.18 | (3.97–4.41) | <0.0001 | 3.75 | (3.56–3.96) | <0.0001 | 50–59 | 9.58 | (9.1–10.08) | <0.0001 | 7.27 | (6.90–7.67) | <0.0001 | ≥60 | 25.70 | (24.54–26.92) | <0.0001 | 16.17 | (15.37–17.00) | <0.0001 | Comorbidity | | | | | | | Asthma (ref = no) | | | | | | | Yes | 2.42 | (2.32–2.53) | <0.0001 | 1.07 | (1.03–1.12) | 0.0019 | Allergic rhinitis (ref = no) | | | | | | | Yes | 1.02 | (0.97–1.06) | 0.4694 | 0.95 | (0.91–0.99) | 0.0158 | Urticaria (ref = no) | | | | | | | Yes | 1.12 | (1.07–1.17) | <0.0001 | 0.99 | (0.94–1.04) | 0.6715 | DM (ref = no) | | | | | | | Yes | 4.20 | (4.07–4.33) | <0.0001 | 1.35 | (1.30–1.39) | <0.0001 | Hypertension (ref = no) | | | | | | | Yes | 6.26 | (6.1–6.43) | <0.0001 | 1.87 | (1.82–1.93) | <0.0001 | Hyperlipidemia (ref = no) | | | | | | | Yes | 3.08 | (2.97–3.18) | <0.0001 | 1.00 | (0.96–1.04) | 0.9719 | AF (ref = no) | | | | | | | Yes | 7.04 | (6.28–7.9) | <0.0001 | 1.68 | (1.50–1.89) | <0.0001 | Treatment (ref = non-TCM and nonsystemic steroid) | | | | | | | Only TCM | 0.98 | (0.90–1.06) | 0.5871 | 1.22 | (1.13–1.32) | <0.0001 | Only systemic steroid | 2.19 | (2.03–2.36) | <0.0001 | 1.55 | (1.43–1.67) | <0.0001 | TCM and systemic steroid | 1.66 | (1.55–1.77) | <0.0001 | 1.64 | (1.53–1.76) | <0.0001 |
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HR: hazard ratio; CI: confidence interval. Adjusted HR: adjusted for age, gender, treatment, and comorbidity in Cox proportional hazards regression.
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