Research Article

Preclinical Evaluation on the Tumor Suppression Efficiency and Combination Drug Effects of Fermented Wheat Germ Extract in Human Ovarian Carcinoma Cells

Figure 1

FWGE treatment inhibited SKOV-3 and ES-2 cell growth. (a) SKOV-3 and ES-2 cells were treated with 0 to 1000 μg/mL for 24 h and 48 h. The data were indicated as the mean ± the standard deviation. (b) Distribution of the cell diameter. Above, SKOV-3 and ES-2 treated with a normal culture medium; below, SKOV-3 and ES-2 cells treated with 600 μg/mL or 200 μg/mL of FWGE, respectively (approximately 50% inhibition of cell growth). Arrows indicate the cell diameter of 12 μM; (c) morphological observation of SKOV-3 and ES-2 cells. Above, SKOV-3 cells were treated with a normal culture medium (left) or 600 μg/mL of FWGE (right) for 48 h; below, ES-2 cells were treated with a normal culture medium (left) or 200 μg/mL of FWGE for 48 h. The arrows indicate the morphological changes that were observed in FWGE-treated cells.
(a)
(b)
(c)