Chinese Herbal Medicine Combined with Conventional Therapy for Blood Pressure Variability in Hypertension Patients: A Systematic Review of Randomized Controlled Trials

Table 4

Herbal medicines and adverse effects in the included trials.

Name of herbal medicines	Formulation	Compositions	Adverse events	Study ID
Xiandan tongmai	Decoction	Herba Epimedii Brevicornus 15 g, Rumulus Ginnamomi 10 g, Radix Salviae Miltiorrhizae 15 g, Fructus Macrocarpii 10 g, Fructus Lycii 10 g, Herba Taxilli Chinensis 10 g, Cortex Eucommiae 10 g, Radix Notoginseng 3 g, Radix Angelicae Sinensis 10 g, Rhizoma Chanxiong 10 g, Rhizoma Anemarrhenae 6 g, Cortex Phellodendri Amurensis 6 g, Radix Achyranthis Bidentatae 10 g	Two patients felt gastrointestinal discomfort and sick in treatment group, but symptoms disappeared with medication after meal instead	Kang and Fan 2013 [22]
Xuezhikang	Capsule	Ultivarietas Oryzae Sativae et Monasci (dosage not available)	Not reported	Li 2012 [24]
Gouteng siwu	Decoction	Herba Taxilli Chinensis 12 g, Radix Achyranthis Bidentatae 12 g, Ramulus Uncariae Rhynchophyllae cum Uncis 30 g, Concha Haliotidis 20 g, Rhizoma Gastrodiae 15 g, Rhizoma Chanxiong 15 g, Rhizoma et Radix Notopterygii 6 g, Radix Rehmanniae 15 g, Radix Paeoniae Alba 15 g	One patient had mild nausea and felt epigastric discomfort for two days, but symptoms were relieved by themselves without treatment or stopping medication	Liang 2011 [28]
Xiang tian ma	Decoction	Ziziphora Clinopodioides Lam 12 g, Radix et Rhizoma Rhodiolae Kirilowii 12 g, Radix Rehmanniae 12 g, Flos Rosae Rugosae 12 g, Apocynum venetum L 20 g, and so on	Not observed	Ma et al. 2013 [23]
Qianyang yuyin	Decoction	Herba Bidentis Bipinnatae, Radix Scrophulariae, Fructus Macrocarpii, Radix Polygoni Multiflori, Rhizoma Alismatis, Radix Achyranthis Bidentatae (dosage not available)	Not reported	Ma 2013 [18]
Tianma shuxin	Granule	Rhizoma Gastrodiae, Radix Achyranthis Bidentatae, Concha Ostreae, Radix Paeoniae Rubra, Cocculus orbiculatus (L.) DC, Rhizoma Alismatis, Radix Scrophulariae, Hirudo (dosage not available)	In treatment group, one had mild nausea, one had epigastric fullness, and one had increased stool frequency, but symptoms disappeared after 3-4 days without drug withdrawal	Pan 2012 [17]
Sangji wendan	Decoction	Folium Mori 10 g, Fructus Tribuli 10 g, Rhizoma Gastrodiae 10 g, Dendranthema lavandulifolium (Fisch. ex Trautv.) Ling et Shih 10 g, Ramulus Uncariae Rhynchophyllae cum Uncis 12 g, Concha Haliotidis 30 g, Pericarpium Citri Reticulatae 6 g, Rhizoma Pinelliae (processed with ginger) 10 g, Fructus Aurantii Immaturus 10 g, poria 12 g, Fructus et Semen Trichosanthis Kirilowii 12 g, Caulis Bambusae in Taeniam 6 g	Not observed	Shi 2011 [20]
Tiao ping kang	Tablet	Fructus Ligustri Lucidui, Herba Epimedii Brevicornus, Caulis et Folium Polygoni Multiflori, Herba Leonuri Japonici, ilex pubescens hook. et arn. and so on (dosage not available)	Not reported	Yan 2008 [27]
Yin gan jing	Decoction	Ramulus Uncariae Rhynchophyllae cum Uncis 20 g, Fructus Evodiae Rutaecarpae 15 g	Not reported	Zhang et al. 2012 [26]
Yangxue qingnao	Granule	Radix Angelicae Sinensis, Rhizoma Chanxiong, Ramulus Uncariae Rhynchophyllae cum Uncis, Radix Paeoniae Alba, Concha Margaritifera Usta, Spica Prunellae Vulgaris, Radix Rehmanniae preparata, Semen Cassiae Obtusifoliae, and so on (dosage not available)	Two patients felt stomach discomfort: symptoms disappeared after medication after meal	Ji and Han 2011 [25]
Qin dan	Capsule	Radix Scutellariae Baicalensis, Rhizoma Coptidis, Ramulus Uncariae Rhynchophyllae cum Uncis, Radix Salviae Miltiorrhizae, Rhizoma Chanxiong, Pheretima Aspergillum, Herba Leonuri Japonici, Herba Taxilli Chinensis (dosage not available)	Not reported	Liang 2007 [19]
Songling Xuemaikang	Capsule	Radix Puerariae Lobatae, Margarita, Folium Pini Massonianae; (dosage not available)	Not reported	Wang 2011 [21]
Qing xuan	Granule	Rhizoma Gastrodiae 30 g, Folium Ilicis Cornutae Immaturum 30 g, Cortex Eucommiae 30 g, Radix Scutellariae Baicalensis 15 g, Folium Ilicis Cornutae Immaturum 15 g	Two patients complained of dizziness and then stopped taking this drug. One had lobar pneumonia and then took other medicines. Four cases were lost to follow-up	Chen 2012 [29]

Not reported: the article did not report any information about adverse effects. Not observed: the article reported that no adverse effects were observed in the studies.