Inhibitory Properties of Aqueous Ethanol Extracts of Propolis on Alpha-Glucosidase

Table 2

Inhibition of propolis extracts against yeast and rat intestinal alpha-glucosidase.

Aqueous ethanol extracts of propolis (EEP)	IC50 (μg/mL)
	Baker’s yeast alpha-glucosidase	Rat intestinal sucrase	Rat intestinal maltase
WEP	16.0 ± 1.38^bc	37.91 ± 0.52^ab	32.67 ± 0.24^e
25% EEP	11.32 ± 2.23^ab	40.25 ± 0.97^ab	44.80 ± 0.25^d
50% EEP	12.90 ± 1.14^b	53.12 ± 0.95^b	100.60 ± 2.95^b
75% EEP	7.24 ± 1.16^a	32.34 ± 0.61^a	71.82 ± 2.95^c
95% EEP	16.26 ± 0.43^bc	32.91 ± 0.54^a	102.76 ± 1.47^b
100% EEP	20.01 ± 1.54^c	38.06 ± 0.56^ab	131.12 ± 1.83^a
Acarbose	177.47 ± 6.28^d	538.30 ± 26.69^c	22.46 ± 0.86^f

Note: Water extracts of propolis were expressed as WEP. Extracts of propolis using 25%, 50%, 75%, 95%, and 100% (in water, v/v) aqueous ethanol solvents were expressed as 25% EEP, 50% EEP, 75% EEP, 95% EEP, and 100% EEP, respectively. Dates are mean ± standard deviation (). Values in the same column followed by the same lower case letter are not significantly different by Duncan’s multiple range test ( < 0.05). Inhibition of propolis extracts against yeast and rat intestinal alpha-glucosidase were both expressed as IC₅₀ (concentration of total phenolics able to scavenger 50% of alpha-glucosidase activity).