Interferon-γ-Mediated Natural Killer Cell Activation by an Aqueous Panax ginseng Extract

Figure 4

Activation of NK cytotoxicity by oral administration of aqueous P. ginseng extract, but not by administration of the ginsenosides, Rb1 and Rg1. WT B6 mice ( in each group) were administered with aqueous extract of P. ginseng (40 mg/kg), mixtures of the indicated amounts of Rb1 and/or Rg1, or the same volume (200 μL) of water on days -2 and -1 as indicated. Liver and spleen MNCs were prepared and cytotoxicity was analyzed using YAC-1 cells at the indicated effector/target ratios. Data are shown as mean ± SD of triplicate samples of all tested mice. Similar results were obtained in three independent experiments. compared with the control at all effector/target ratios.