Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 615384, 9 pages
http://dx.doi.org/10.1155/2015/615384
Review Article

Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain

1Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia
2Department of Neurology, Boston University School of Medicine and Framingham Heart Study, Boston, MA 02118, USA

Received 19 January 2015; Revised 26 March 2015; Accepted 10 April 2015

Academic Editor: Abid Hamid

Copyright © 2015 Tamara Simpson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The detrimental effect of neuronal cell death due to oxidative stress and mitochondrial dysfunction has been implicated in age-related cognitive decline and neurodegenerative disorders such as Alzheimer’s disease. The Indian herb Bacopa monnieri is a dietary antioxidant, with animal and in vitro studies indicating several modes of action that may protect the brain against oxidative damage. In parallel, several studies using the CDRI08 extract have shown that extracts of Bacopa monnieri improve cognitive function in humans. The biological mechanisms of this cognitive enhancement are unknown. In this review we discuss the animal studies and in vivo evidence for Bacopa monnieri as a potential therapeutic antioxidant to reduce oxidative stress and improve cognitive function. We suggest that future studies incorporate neuroimaging particularly magnetic resonance spectroscopy into their randomized controlled trials to better understand whether changes in antioxidant status in vivo cause improvements in cognitive function.