Evidence-Based Complementary and Alternative Medicine

Research Article

Research of Herb-Partitioned Moxibustion for Primary Dysmenorrhea Patients Based on the LC-MS Metabonomics

Table 1

The main probable materials of two groups.


Group	ESI	Monoisotopic molecular weight	Formula	Metabolites	Related pathway	VIP	Changed fold^a

A	+	270.1620	C₁₈H₂₂O₂	Estrone	Steroid hormone biosynthesis	1.56605	↓
A	+	316.2402	C₂₁H₃₂O₂	20α-Dihydroprogesterone	Steroid hormone biosynthesis	1.30279	↑
A	+	316.2402	C₂₁H₃₂O₂	Pregnenolone	Steroid hormone biosynthesis	1.30279	↑
A	+	352.2250	C₂₀H₃₂O₅	Prostaglandin E₂	Steroid hormone biosynthesis	1.47588	↑
A	+	352.2250	C₂₀H₃₂O₅	Prostaglandin H2	Arachidonic acid metabolism	1.47588	↓
A	+	103.0633	C₄H₉NO₂	Gamma-Aminobutyric acid	GABAergic synapse	1.3201	↑
A	−	284.1412	C₁₈H₂₀O₃	16-Oxoestrone	Steroid hormone biosynthesis	1.10038	↓
B	+	316.2038	C₂₀H₂₈O₃	2-Methoxyestradiol-3-methylether	Steroid hormone biosynthesis	1.59796	↓
B	+	316.2402	C₂₁H₃₂O₂	20α-Dihydroprogesterone	Steroid hormone biosynthesis	1.12801	↑
B	+	316.2402	C₂₁H₃₂O₂	Pregnenolone	Steroid hormone biosynthesis	1.12801	↑
B	+	322.25	C₂₀H₃₄O₃	15-Hydroxyeicosatrienoic acid	Arachidonic acid metabolism	1.47681	↓
B	−	370.2356	C₂₀H₃₄O₆	6-Keto-prostaglandin	Arachidonic acid metabolism	2.46181	↓

^acompared to the content before treatment. Arrow (↑) indicated relative increasing in signal. Arrow (↓) indicated relative decreasing in signal. Differences with were considered significant.