Shenqi Fuzheng Injection Combined with Chemotherapy for Breast Cancer: A Meta-Analysis of Randomized Controlled Trials

Table 1

Study characteristics and quality.

First author, year,; country	Sample size; (E/C)	Age; (F)	TNM	Intervention; (E/C)	Treatment course; (C/W/D)	KPS	Jadad score
Xie, 2014, [22]; China	45/45	35~68	—	SFI + CAF	4~6 C,; 3 W/C	—	4
Liang, 2014, [23]; China	27/27	29~57	III-IV	SFI + CTF	2 C, 21 D/C	≥60	3
Zhang, 2013, [24] China	32/32	32–67	—	SFI + GEM, CDDP	21 D	≥60	4
Kawuli, 2011, [25] China	40/40	28~65	III-IV	SFI + TPX,; E-ADM	3 C, 3 W/C,; 7 D/W	≥60	3
Xu, 2010, [26]; China	28/24	47/49	—	SFI + TA	4 C, 21 D/C	≥60	3
Huang, 2008, [27]; China	30/30	47/46	III-IV	SFI + CTF	2 C, 21 D/C	≥60	4
Yuan, 2008, [28]; China	38/35	19~60	II-III	SFI + CAF	20 D	>60	3
Zhu, 2008, [29]; China	32/24	52.5/51	I–III	SFI + CEF	10 D	—	4
Qiu, 2010, [30]; China	24/23	52.04/52.17	III-IV	SFI + TPX,; E-ADM	2 C, 3 W/C	≥60	3
Dai, 2007, [31]; China	65/61	26~70	II-III	SFI + CEF	2 C, 28 D/C	>80	3
Chen, 2007, [32]; China	34/34	38~64	I-II	SFI + CEF	6 C, 21 D/C	—	3
Wang, 2006, [33]; China	40/32	45.2 ± 9.8/46.7 ± 0.5	—	SFI + 5-FU,; E-ADM, CTX	6 C, 21 D/C	≥60	3
Xiao, 2005, [34]; China	55/53	43~63	—	SFI + FEC	8 D	≥60	3
Li, 2004, [35]; China	40/35	56.4/54.2	IV	SFI + NE	3 C, 28 D/C	≥80	3
Cui, 2011, [36]; China	22/20	33~62	—	SFI + FAC, AC	4–6 C,; 5–8 D/C	>80	3
Li, 2002, [37]; China	35/27	47.2 ± 10.8/46.7 ± 10.5	—	SFI + 5-FU,; CTX, MMC	3 C, 21 D/C	>50	3
Song, 2004, [38] China	21/25	52/58	II-III	SFI + CMF	2 C, 2 W/C	—	3
Wu, 2012, [39]; China	36/36	35~69	—	SFI + CMF	4 C, 28 D/C	—	3

Note: E/C: experimental group/control group; F: female; TNM: T: tumor, N: lymph node, and M: metastasis; C: cycle; W: week; D: day; KPS: Karnofsky; SFI: shenqi fuzheng injection; CAF: CTX (cyclophosphamide) and ADM (Adriamycin) and 5-FU (5-fluorouracil); CTF: CTX and THP (Therarubicin) and 5-FU; TA: PTX (Paclitaxel) and E-ADM/EPI (epirubicin); CEF: CTX and E-ADM/EPI and 5-FU; TE: PTX and EPI; FEC: CTX and 5-FU and EPI; NE: NVB (Vinorelbine) and E-ADM; FAC: 5-FU and ADM and CTX; AC: ADM and CTX; CMF: CTX and MTX (Methotrexate) and 5-FU; CDDP: cisplatin; MMC: mitomycin; GEM: gemcitabine; Jadad score: modified Jadad scale that was used.