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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 640846, 12 pages
http://dx.doi.org/10.1155/2015/640846
Research Article

Methyl Protodioscin from the Roots of Asparagus cochinchinensis Attenuates Airway Inflammation by Inhibiting Cytokine Production

1College of Pharmacy, Kangwon National University, Chuncheon 200-701, Republic of Korea
2Department of Food and Nutrition, Andong National University, Andong 760-749, Republic of Korea
3College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea
4College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea

Received 31 March 2015; Revised 14 July 2015; Accepted 21 July 2015

Academic Editor: Orazio Taglialatela-Scafati

Copyright © 2015 Ju Hee Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. K. Jeffery, “Remodeling in asthma and chronic obstructive lung disease,” American Journal of Respiratory and Critical Care Medicine, vol. 164, no. 10, pp. S28–S38, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. F. A. Al-Kassimi and E. H. Alhamad, “A challenge to the seven widely believed concepts of COPD,” International Journal of COPD, vol. 8, pp. 21–30, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Guo, M. H. Pittler, and E. Ernst, “Herbal medicines for the treatmet of COPD: a systematic review,” European Respiratory Journal, vol. 28, no. 2, pp. 330–338, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Sharma, J. T. Arnason, A. Burt, and J. B. Hudson, “Echinacea extracts modulate the pattern of chemokine and cytokine secretion in rhinovirus-infected and uninfected epithelial cells,” Phytotherapy Research, vol. 20, no. 2, pp. 147–152, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. T. B. Agbabiaka, R. Guo, and E. Ernst, “Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis,” Phytomedicine, vol. 15, no. 5, pp. 378–385, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Matthys and P. Funk, “EPs 7630 improves acute bronchitic symptoms and shortens time to remission. Results of a randomised, double-blind, placebo-controlled, multicentre trial,” Planta Medica, vol. 74, no. 6, pp. 686–692, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. H. J. Lim, H.-G. Jin, E.-R. Woo, S. K. Lee, and H. P. Kim, “The root barks of Morus alba and the flavonoid constituents inhibit airway inflammation,” Journal of Ethnopharmacology, vol. 149, no. 1, pp. 169–175, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Bae, “Asparagus cochinchinensis,” in The Medicinal Plants of Korea, p. 527, Kyohak Publishing, Seoul, Republic of Korea, 2000. View at Google Scholar
  9. K. Tenji and S. Junzo, “Studies on the constituents of asparagi radix. I. On the structures of furostanol oligosides of Asparagus cochinchinensis (Loureio) Merrill,” Chemical and Pharmaceutical Bulletin, vol. 27, no. 12, pp. 3086–3094, 1979. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Shen, C.-L. Xu, W.-D. Xuan et al., “A new furostanol saponin from Asparagus cochinchinensis,” Archives of Pharmacal Research, vol. 34, no. 10, pp. 1587–1591, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. G.-L. Zhu, Q. Hao, R.-T. Li, and H.-Z. Li, “Steroidal saponins from the roots of Asparagus cochinchinensis,” Chinese Journal of Natural Medicines, vol. 12, no. 3, pp. 213–217, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Y. Lee, B. K. Choo, T. Yoon et al., “Anti-inflammatory effects of Asparagus cochinchinensis extract in acute and chronic cutaneous inflammation,” Journal of Ethnopharmacology, vol. 121, no. 1, pp. 28–34, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Kim, E. Lee, T. Lim, J. Jung, and Y. Lyu, “Inhibitory effect of Asparagus cochinchinensis on tumor necrosis factor-alpha secretion from astrocytes,” International Journal of Immunopharmacology, vol. 20, no. 4-5, pp. 153–162, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Jian, K.-W. Zeng, J. Li, N. Li, Y. Jiang, and P. Tu, “Anti-neuroinflammatory constituents from Asparagus cochinchinensis,” Fitoterapia, vol. 84, no. 1, pp. 80–84, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Lee, Y. Kim, H. J. Kim et al., “Herbal formula, PM014, attenuates lung inflammation in a murine model of chronic obstructive pulmonary disease,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 769830, 10 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. K.-H. Jung, H.-L. Choi, S. Park et al., “The effects of the standardized herbal formula PM014 on pulmonary inflammation and airway responsiveness in a murine model of cockroach allergen-induced asthma,” Journal of Ethnopharmacology, vol. 155, no. 1, pp. 113–122, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Ju and Z.-J. Jia, “Steroidal saponins from the rhizomes of Smilax menispermoidea,” Phytochemistry, vol. 31, no. 4, pp. 1349–1351, 1992. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Mosmann, “Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays,” Journal of Immunological Methods, vol. 65, no. 1-2, pp. 55–63, 1983. View at Publisher · View at Google Scholar · View at Scopus
  19. H. J. Ko, J. H. Jin, O. S. Kwon, J. T. Kim, K. H. Son, and H. P. Kim, “Inhibition of experimental lung inflammation and bronchitis by phytoformula containing Broussonetia papyrifera and Lonicera japonica,” Biomolecules and Therapeutics, vol. 19, no. 3, pp. 324–330, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. R. W. Chapman, M. Minnicozzi, C. S. Celly et al., “A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation,” Journal of Pharmacology and Experimental Therapeutics, vol. 322, no. 2, pp. 486–493, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Mueller, P. Chanez, A. M. Campbell, J. Bousquet, C. Heusser, and G. R. Bullock, “Different cytokine patterns in bronchial biopsies in asthma and chronic bronchitis,” Respiratory Medicine, vol. 90, no. 2, pp. 79–85, 1996. View at Publisher · View at Google Scholar · View at Scopus
  22. H. Wu, S. Yang, X. Wu et al., “Interleukin-33/ST2 signaling promotes production of interleukin-6 and interleukin-8 in systemic inflammation in cigarette smoke-induced chronic obstructive pulmonary disease mice,” Biochemical and Biophysical Research Communications, vol. 450, no. 1, pp. 110–116, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Sichelstiel, K. Yadava, A. Trompette et al., “Targeting IL-1β and IL-17A driven inflammation during influenza-induced exacerbations of chronic lung inflammation,” PLoS ONE, vol. 9, no. 6, Article ID e98440, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Zhang, S. Gilbert, X. Yao et al., “Natural compound methyl protodioscin protects against intestinal inflammation through modulation of intestinal immune responses,” Pharmacology Research and Perspective, vol. 3, no. 2, Article ID e00118, 2015. View at Publisher · View at Google Scholar
  25. Y. Shao, O. Poobrasert, E. J. Kennelly et al., “Steroidal saponins from Asparagus officinalis and their cytotoxic activity,” Planta Medica, vol. 63, no. 3, pp. 258–262, 1997. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Hu and X. Yao, “The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro,” Cancer Investigation, vol. 21, no. 3, pp. 389–393, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. G. Wang, H. Chen, M. Huang et al., “Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells,” Cancer Letters, vol. 241, no. 1, pp. 102–109, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Y. Kim, K. H. Son, H. W. Chang, S. S. Kang, and H. P. Kim, “Inhibition of mouse ear edema by steroidal and triterpenoid saponins,” Archives of Pharmacal Research, vol. 22, no. 3, pp. 313–316, 1999. View at Publisher · View at Google Scholar · View at Scopus
  29. H. J. Lee, J. S. Park, Y. P. Yoon et al., “Dioscin and methylprotodioscin isolated from the root of Asparagus cochinchinensis suppressed the gene expression and production of airway MUC5AC mucin induced by phorbol ester and growth factor,” Phytomedicine, vol. 22, no. 5, pp. 568–572, 2015. View at Publisher · View at Google Scholar
  30. T. Jiang, X.-Y. Tang, J.-S. Wu et al., “Study on chemical constituents of the root of Liriope platyphylla,” Zhong Yao Cai, vol. 34, no. 10, pp. 1537–1539, 2011. View at Google Scholar · View at Scopus
  31. K. Bae, “Liriope platyphylla,” in The Medicinal Plants of Korea, p. 536, Kyo-Hak Publishing, Seoul, Republic of Korea, 2000. View at Google Scholar