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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 643654, 10 pages
http://dx.doi.org/10.1155/2015/643654
Research Article

The Roots of Atractylodes macrocephala Koidzumi Enhanced Glucose and Lipid Metabolism in C2C12 Myotubes via Mitochondrial Regulation

1Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University, Gyeongju 707, Republic of Korea
2Korean Medicine R&D Center, College of Korean Medicine, Dongguk University, Gyeongju 707, Republic of Korea
3Department of Herbology, College of Korean Medicine, Dongguk University, Gyeongju 707, Republic of Korea

Received 27 May 2015; Revised 18 September 2015; Accepted 18 October 2015

Academic Editor: Evan P. Cherniack

Copyright © 2015 Mi Young Song et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C.-H. Wang, C.-C. Wang, and Y.-H. Wei, “Mitochondrial dysfunction in insulin insensitivity: implication of mitochondrial role in type 2 diabetes,” Annals of the New York Academy of Sciences, vol. 1201, pp. 157–165, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. J.-A. Kim, Y. Wei, and J. R. Sowers, “Role of mitochondrial dysfunction in insulin resistance,” Circulation Research, vol. 102, no. 4, pp. 401–414, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. P. M. Garcia-Roves, “Mitochondrial pathophysiology and type 2 diabetes mellitus,” Archives of Physiology and Biochemistry, vol. 117, no. 3, pp. 177–187, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. B. B. Lowell and G. I. Shulman, “Mitochondrial dysfunction and type 2 diabetes,” Science, vol. 307, no. 5708, pp. 384–387, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. D. E. Kelley, J. He, E. V. Menshikova, and V. B. Ritov, “Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes,” Diabetes, vol. 51, no. 10, pp. 2944–2950, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Krssak, K. Falk Petersen, A. Dresner et al., “Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study,” Diabetologia, vol. 42, no. 1, pp. 113–116, 1999. View at Google Scholar
  7. A. V. Greco, G. Mingrone, A. Giancaterini et al., “Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion,” Diabetes, vol. 51, no. 1, pp. 144–151, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Cantó and J. Auwerx, “PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure,” Current Opinion in Lipidology, vol. 20, no. 2, pp. 98–105, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Liang and W. F. Ward, “PGC-1α: a key regulator of energy metabolism,” American Journal of Physiology—Advances in Physiology Education, vol. 30, no. 4, pp. 145–151, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. D. G. Hardie and K. Sakamoto, “AMPK: a key sensor of fuel and energy status in skeletal muscle,” Physiology, vol. 21, no. 1, pp. 48–60, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. N. B. Ruderman, X. J. Xu, L. Nelson et al., “AMPK and SIRT1: a long-standing partnership?” The American Journal of Physiology—Endocrinology and Metabolism, vol. 298, no. 4, pp. E751–E760, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Liu, W. Shen, B. Zhao et al., “Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: hope from natural mitochondrial nutrients,” Advanced Drug Delivery Reviews, vol. 61, no. 14, pp. 1343–1352, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Suwa, T. Egashira, H. Nakano, H. Sasaki, and S. Kumagai, “Metformin increases the PGC-1α protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo,” Journal of Applied Physiology, vol. 101, no. 6, pp. 1685–1692, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Fujisawa, T. Nishikawa, D. Kukidome et al., “TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis,” Biochemical and Biophysical Research Communications, vol. 379, no. 1, pp. 43–48, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Lagouge, C. Argmann, Z. Gerhart-Hines et al., “Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α,” Cell, vol. 127, no. 6, pp. 1109–1122, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. C.-Q. Li, L.-C. He, and J.-Q. Jin, “Atractylenolide I and atractylenolide III inhibit lipopolysaccharide-induced TNF-α and NO production in macrophages,” Phytotherapy Research, vol. 21, no. 4, pp. 347–353, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. C.-Q. Li, L.-C. He, H.-Y. Dong, and J.-Q. Jin, “Screening for the anti-inflammatory activity of fractions and compounds from Atractylodes macrocephala koidz,” Journal of Ethnopharmacology, vol. 114, no. 2, pp. 212–217, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Matsuda, Y. H. Li, K. Taniguchi, J. Yamahara, and Y. Tamai, “Imaging analysis of antiulcer action and the active constituent of Atractylodis rhizoma,” Yakugaku Zasshi, vol. 111, no. 1, pp. 36–39, 1991. View at Google Scholar
  19. H. Mori, Q. Xu, O. Sakamoto, Y. Uesugi, A. Koda, and I. Nishioka, “Mechanisms of antitumor activity of aqueous extracts from Chinese herbs: their immunopharmacological properties,” Japanese Journal of Pharmacology, vol. 49, no. 3, pp. 423–431, 1989. View at Publisher · View at Google Scholar · View at Scopus
  20. I. Kimura, “Medical benefits of using natural compounds and their derivatives having multiple pharmacological actions,” Yakugaku Zasshi, vol. 126, no. 3, pp. 133–143, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. C. K. Kim, M. Kim, S. D. Oh et al., “Effects of Atractylodes macrocephala Koidzumi rhizome on 3T3-L1 adipogenesis and an animal model of obesity,” Journal of Ethnopharmacology, vol. 137, no. 1, pp. 396–402, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Han, H. W. Jung, and Y.-K. Park, “The roots of Atractylodes japonica Koidzumi promote adipogenic differentiation via activation of the insulin signaling pathway in 3T3-L1 cells,” BMC Complementary and Alternative Medicine, vol. 12, article 154, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. M. Y. Song, H. W. Jung, S. Y. Kang, K.-H. Kim, and Y.-K. Park, “Anti-inflammatory effect of lycii radicis in LPS-stimulated RAW 264.7 macrophages,” American Journal of Chinese Medicine, vol. 42, no. 4, pp. 891–904, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Schrauwen and M. Hesselink, “UCP2 and UCP3 in muscle controlling body metabolism,” Journal of Experimental Biology, vol. 205, no. 15, pp. 2275–2285, 2002. View at Google Scholar · View at Scopus
  25. M. E. Patti, A. J. Butte, S. Crunkhorn et al., “Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 14, pp. 8466–8471, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. S. H. Park, S. R. Gammon, J. D. Knippers, S. R. Paulsen, D. S. Rubink, and W. W. Winder, “Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle,” Journal of Applied Physiology, vol. 92, no. 6, pp. 2475–2482, 2002. View at Google Scholar · View at Scopus
  27. L. Bordone and L. Guarente, “Calorie restriction, SIRT1 and metabolism: understanding longevity,” Nature Reviews Molecular Cell Biology, vol. 6, no. 4, pp. 298–305, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. D. G. Hardie, “AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy,” Nature Reviews Molecular Cell Biology, vol. 8, no. 10, pp. 774–785, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. C.-H. Wang, K.-T. Chi, and Y.-H. Wei, “Mitochondrial dysfunction in insulin insensitivity and type 2 diabetes and new insights for their prevention and management,” in Insulin Resistance, p. 27, InTech, 2012. View at Google Scholar
  30. K. F. Petersen, D. Befroy, S. Dufour et al., “Mitochondrial dysfunction in the elderly: possible role in insulin resistance,” Science, vol. 300, no. 5622, pp. 1140–1142, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. G. Boden, “Obesity and free fatty acids,” Endocrinology and Metabolism Clinics of North America, vol. 37, no. 3, pp. 635–646, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. S. M. Houten and R. J. A. Wanders, “A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation,” Journal of Inherited Metabolic Disease, vol. 33, no. 5, pp. 469–477, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. J. S. Armstrong, “Mitochondrial medicine: pharmacological targeting of mitochondria in disease,” British Journal of Pharmacology, vol. 151, no. 8, pp. 1154–1165, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. D. Kirpichnikov, S. I. McFarlane, and J. R. Sowers, “Metformin: an update,” Annals of Internal Medicine, vol. 137, no. 1, pp. 25–33, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. R. C. Scarpulla, “Transcriptional paradigms in mammalian mitochondrial biogenesis and function,” Physiological Reviews, vol. 88, no. 2, pp. 611–638, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. Z. Gerhart-Hines, J. T. Rodgers, O. Bare et al., “Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α,” The EMBO Journal, vol. 26, no. 7, pp. 1913–1923, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. J. Zhou, F. Qu, and Y. Yu, “Chemical and ecological evaluation of a genuine Chinese medicine: Atractylodes macrocephala Koidz,” African Journal of Traditional, Complementary and Alternative Medicines, vol. 8, no. 4, pp. 405–411, 2011. View at Publisher · View at Google Scholar · View at Scopus