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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 646872, 7 pages
Research Article

Effect of Acupuncture on Functional Connectivity of Anterior Cingulate Cortex for Bell’s Palsy Patients with Different Clinical Duration

1Medical Information Engineering, Anhui University of Chinese Medicine, Hefei, Anhui 230012, China
2Laboratory of Digital Medical Imaging, Medical Imaging Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, China
3Department of Biomedical Engineering, Kyung Hee University, Yongin 446701, Republic of Korea

Received 5 December 2014; Revised 31 March 2015; Accepted 16 April 2015

Academic Editor: Jian Kong

Copyright © 2015 Hongli Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acupuncture is widely used in the treatment of Bell’s palsy (BP) in many countries, but its underlying physiological mechanism remained controversial. In order to explore the potential mechanism, changes of functional connectivity (FC) of anterior cingulate gyrus (ACC) were investigated. We collected 20 healthy (control group) participants and 28 BP patients with different clinical duration accepted resting state functional MRI (rfMRI) scans before and after acupuncture, respectively. The FC of ACC before and after acupuncture was compared with paired -test and the detailed results are presented in the paper. Our results showed that effects of the acupuncture on FC were closely related to clinical duration in patients with BP, which suggested that brain response to acupuncture was closely connected with the status of brain functional connectivity and implied that acupuncture plays a homeostatic role in the BP treatment.