Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s)

Figure 4

Insulin sensitivity of normal and STZ-diabetic rats treated with curcumin incorporated in yoghurt. Glycemia levels after insulin administration in rats treated for 1 day ((a) diabetic; (b) normal) and for 15 days ((c) diabetic; (d) normal) with curcumin. The inserted table shows the values (%/min), which were calculated as percentage of the respective control group (DYOG or NYOG). Values are expressed as means ± SEM, -8 per group. Differences between groups were analyzed with one-way ANOVA followed by Student-Newman-Keuls test (). : differences with DYOG.