Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s)

Table 2

Stability of curcumin in plasma under different conditions of storage, temperature, and time intervals ().

Sample condition	Curcumin nominal concentration
	25 ng/mL		400 ng/mL
	Accuracy (%)	Precision CV (%)	Accuracy (%)	Precision CV (%)
Bench-top (30°C, 4 h)	91.85	8.90	105.90	12.50
Postprocessing (30°C, 4 h)	88.45	7.50	101.56	13.40
Freeze-thaw (−20°C, 72 h)	89.34	5.40	99.47	11.60
Long time (−20°C, 7 d)	90.77	6.20	103.24	8.90