Curcumin Pharmacokinetic and Pharmacodynamic Evidences in Streptozotocin-Diabetic Rats Support the Antidiabetic Activity to Be via Metabolite(s)

Table 4

Pharmacokinetic parameters after oral (500 mg/kg) and i.v. administration (10 mg/kg) of curcumin to STZ-diabetic rats. Values are expressed as means ± SEM ().

Pharmacokinetic parameters	Administration route
	Oral	i.v.
(1/min)	0.02 ± 0.01	0.08 ± 0.02
Half-life (min)	32.70 ± 12.92	8.64 ± 2.31
(g/mL/min)	1.89 ± 0.25	12.27 ± 2.75
(g/mL/min)	2.97 ± 0.79	12.45 ± 2.72
Cl (L/kg/min)	0.85 ± 0.24	0.83 ± 0.19
(L/kg)	37.49 ± 10.46	10.63 ± 4.10
MRT (min)	55.41 ± 20.19	12.46 ± 3.34
(1/min)	0.29 ± 0.15	—
(g/mL)	0.06 ± 0.01	3.14 ± 0.90
(min)	15.00 ± 0.00	5.00 ± 0.00
(%)	0.47 ± 0.12	100

: elimination constant; half-life: time half-life; : area under plasma concentration/time plot until the last quantifiable value; : area under plasma concentration/time plot extrapolated to infinity; Cl: clearance; : volume of distribution; MRT: average mean residence time; : absorption constant; : maximum concentration; : time to reach ; : bioavailability.