Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 679238, 8 pages
http://dx.doi.org/10.1155/2015/679238
Research Article

A Lindera obtusiloba Extract Blocks Calcium-/Phosphate-Induced Transdifferentiation and Calcification of Vascular Smooth Muscle Cells and Interferes with Matrix Metalloproteinase-2 and Metalloproteinase-9 and NF-B

1Department of Pediatric Nephrology and Center for Cardiovascular Research, Charité-University Medicine, Campus Virchow Clinic, 10115 Berlin, Germany
2Department of Beauty Design, Human Environmental Sciences College, Wonkwang University, Iksan 570-749, Republic of Korea

Received 24 March 2015; Revised 10 July 2015; Accepted 13 July 2015

Academic Editor: Roja Rahimi

Copyright © 2015 Christian Freise et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. N. Foley, “Clinical epidemiology of cardiovascular disease in chronic kidney disease,” Journal of Renal Care, vol. 36, supplement 1, pp. 4–8, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Mizobuchi, D. Towler, and E. Slatopolsky, “Vascular calcification: the killer of patients with chronic kidney disease,” Journal of the American Society of Nephrology, vol. 20, no. 7, pp. 1453–1464, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. C. M. Shanahan, N. R. B. Cary, J. R. Salisbury, D. Proudfoot, P. L. Weissberg, and M. E. Edmonds, “Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification,” Circulation, vol. 100, no. 21, pp. 2168–2176, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Nasri, A. Baradaran, H. Shirzad, and M. R. Kopaei, “New concepts in nutraceuticals as alternative for pharmaceuticals,” International Journal of Preventive Medicine, vol. 5, no. 12, pp. 1487–1499, 2014. View at Google Scholar · View at Scopus
  5. F. Stickel and D. Schuppan, “Herbal medicine in the treatment of liver diseases,” Digestive and Liver Disease, vol. 39, no. 4, pp. 293–304, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Yook, “Lindera obtusiloba,” in Medical Plants of Korea, p. 184, Jinmyeong Publishing, Seoul, Republic of Korea, 1989. View at Google Scholar
  7. C. Freise, U. Erben, U. Neuman et al., “An active extract of Lindera obtusiloba inhibits adipogenesis via sustained Wnt signaling and exerts anti-inflammatory effects in the 3T3-L1 preadipocytes,” Journal of Nutritional Biochemistry, vol. 21, no. 12, pp. 1170–1177, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Freise, M. Ruehl, U. Erben et al., “A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines,” BMC Complementary and Alternative Medicine, vol. 11, article 39, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Ruehl, U. Erben, K. Kim et al., “Extracts of Lindera obtusiloba induce antifibrotic effects in hepatic stellate cells via suppression of a TGF-beta-mediated profibrotic gene expression pattern,” Journal of Nutritional Biochemistry, vol. 20, no. 8, pp. 597–606, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Trowitzsch-Kienast, M. Rühl, K. Y. Kim et al., “Absolute configuration of antifibrotic (+)-episesamin isolated from Lindera obtusiloba BLUME,” Zeitschrift für Naturforschung Section C, vol. 66, no. 9-10, pp. 460–464, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. C.-O. Hong, H. A. Lee, C. H. Rhee, S.-Y. Choung, and K.-W. Lee, “Separation of the antioxidant compound quercitrin from Lindera obtusiloba blume and its antimelanogenic effect on B16F10 melanoma cells,” Bioscience, Biotechnology and Biochemistry, vol. 77, no. 1, pp. 58–64, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. H. C. Kwon, N. I. Baek, S. U. Choi, and K. R. Lee, “New cytotoxic butanolides from Lindera obtusiloba BLUME,” Chemical and Pharmaceutical Bulletin, vol. 48, no. 5, pp. 614–416, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Y. Lee, S.-H. Kim, E. J. Jeong et al., “New secoisolariciresinol derivatives from Lindera obtusiloba stems and their neuroprotective activities,” Planta Medica, vol. 76, no. 3, pp. 294–297, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Freise and U. Querfeld, “Inhibition of vascular calcification by block of intermediate conductance calcium-activated potassium channels with TRAM-34,” Pharmacological Research, vol. 85, pp. 6–14, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Freise, M. Ruehl, U. Erben, R. W. Farndale, R. Somasundaram, and M. M. Heimesaat, “The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp)10 promotes enzymatic activity of matrixmetalloproteinase-2 in vitro,” European Journal of Microbiology and Immunology, vol. 2, no. 3, pp. 186–191, 2012. View at Publisher · View at Google Scholar
  16. A. E. Jiménez-Corona, S. Damián-Zamacona, A. Pérez-Torres, A. Moreno, and J. Mas-Oliva, “Osteopontin upregulation in atherogenesis is associated with cellular oxidative stress triggered by the activation of scavenger receptors,” Archives of Medical Research, vol. 43, no. 2, pp. 102–111, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Cai, X. Teng, C.-S. Pan, X.-H. Duan, C.-S. Tang, and Y.-F. Qi, “Adrenomedullin up-regulates osteopontin and attenuates vascular calcification via the cAMP/PKA signaling pathway,” Acta Pharmacologica Sinica, vol. 31, no. 10, pp. 1359–1366, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Scatena, L. Liaw, and C. M. Giachelli, “Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 27, no. 11, pp. 2302–2309, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Zarjou, V. Jeney, P. Arosio et al., “Ferritin prevents calcification and osteoblastic differentiation of vascular smooth muscle cells,” Journal of the American Society of Nephrology, vol. 20, no. 6, pp. 1254–1263, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. A. C. Montezano, D. Zimmerman, H. Yusuf et al., “Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium,” Hypertension, vol. 56, no. 3, pp. 453–462, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Liu and C. M. Shanahan, “Signalling pathways and vascular calcification,” Frontiers in Bioscience, vol. 16, no. 4, pp. 1302–1314, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. A. W. Y. Chung, H. H. C. Yang, J. M. Kim et al., “Upregulation of matrix metalloproteinase-2 in the arterial vasculature contributes to stiffening and vasomotor dysfunction in patients with chronic kidney disease,” Circulation, vol. 120, no. 9, pp. 792–801, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. A. W. Y. Chung, H. H. C. Yang, M. K. Sigrist et al., “Matrix metalloproteinase-2 and -9 exacerbate arterial stiffening and angiogenesis in diabetes and chronic kidney disease,” Cardiovascular Research, vol. 84, no. 3, pp. 494–504, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Pai, E. M. Leaf, M. El-Abbadi, and C. M. Giachelli, “Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease,” The American Journal of Pathology, vol. 178, no. 2, pp. 764–773, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. C. M. Shanahan, M. H. Crouthamel, A. Kapustin, and C. M. Giachelli, “Arterial calcification in chronic kidney disease: key roles for calcium and phosphate,” Circulation Research, vol. 109, no. 6, pp. 697–711, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. N. X. Chen, K. D. O'Neill, X. Chen, K. Kiattisunthorn, V. H. Gattone, and S. M. Moe, “Activation of arterial matrix metalloproteinases leads to vascular calcification in chronic kidney disease,” American Journal of Nephrology, vol. 34, no. 3, pp. 211–219, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. X. Qin, M. A. Corriere, L. M. Matrisian, and R. J. Guzman, “Matrix metalloproteinase inhibition attenuates aortic calcification,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 7, pp. 1510–1516, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. S. J. Lee, K. W. Seo, M. R. Yun et al., “4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the Akt/NF-kappaB signaling pathways,” Free Radical Biology and Medicine, vol. 45, no. 10, pp. 1487–1492, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Zhang, Z.-W. Wang, H.-B. Wu et al., “Transforming growth factor-β1 induces matrix metalloproteinase-9 expression in rat vascular smooth muscle cells via ROS-dependent ERK-NF-κB pathways,” Molecular and Cellular Biochemistry, vol. 375, no. 1-2, pp. 11–21, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Kageyama, H. Matsui, M. Ohta et al., “Palmitic acid induces osteoblastic differentiation in vascular smooth muscle cells through ACSL3 and NF-κB, novel targets of eicosapentaenoic acid,” PLoS ONE, vol. 8, no. 6, Article ID e68197, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. H. C. Kwon, S. U. Choi, J. O. Lee, K. H. Bae, O. P. Zee, and K. R. Lee, “Two new lignans from Lindera obtusiloba blume,” Archives of Pharmacal Research, vol. 22, no. 4, pp. 417–422, 1999. View at Publisher · View at Google Scholar · View at Scopus
  32. C. Freise and U. Querfeld, “The lignan (+)-episesamin interferes with TNF-α-induced activation of VSMC via diminished activation of NF-KB, ERK1/2 and AKT and decreased activity of gelatinases,” Acta Physiologica, vol. 213, no. 3, pp. 642–652, 2015. View at Publisher · View at Google Scholar · View at Scopus