Table 4: Levels of neuroinflammatory factors and neurotransmitters in serum before and after EA add-on treatment in the D + EA group, and before and after 2 months in the D group.

D + EA groupD group
Before EAAfter EABefore 2 monthsAfter 2 months

Neuroinflammatory factors
 NO [mmol/L, median (quartile)]29.927 (17.153–51.460)83.108 (63.869–106.081)0.00229.927 (16.970–50.182)116.891 (93.598–145.946)0.000
 IL-1β [pg/mL, median (quartile)]4.160 (2.445–6.187)6.647 (4.191–9.817)0.0557.527 (5.536–8.839)9.170 (5.025–12.279)0.204
 PGE2 [pg/mL, median (quartile)]10.105 (4.167–50.510)9.745 (6.876–16.922)0.2926.081 (4.612–13.875)10.364 (7.449–12.968)0.232
 TNF-α [pg/mL, median (quartile)]63.715 (42.480–70.383)70.741 (44.571–122.699)0.21865.407 (61.229–68.284)81.852 (47.271–114.851)0.058
Neurotransmitters
 NE [μg/mL, median (quartile)]0.132 (0.088~1.021)1.453 (1.216~1.801)0.0020.114 (0.096–1.109)0.799 (0.423–1.382)0.093
 Ach [nmol/L, median (quartile)]0.007 (0.004~0.016)0.011 (0.009~0.014)0.0240.008 (0.005–0.012)0.016 (0.009–0.021)0.445
 DA [μg/mL, median (quartile)]1.688 (0.002~2.737)1.959 (0.764~3.037)0.0731.780 (1.165–2.593) 1.797 (1.162–2.691)0.646
 5-HT [μg/mL, median (quartile)]0.236 (0.143~1.313)0.486 (0.129~1.205)0.7610.232 (0.199–0.301)0.307 (0.169–0.608)0.241

Values are median (lower quartile, upper quartile) for the Wilcoxon signed-rank test.
; .