Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats

Table 1

Effect of different inhibitors/antagonists on the relaxation induced by HEMC of rat aortic rings precontracted with phenylephrine.

Groups	(% Relaxation)	IC50 (µg/mL)
Control E^−	4.1 ± 0.9 (6)^***	nd
Control E^+	99.5 ± 1.4 (6)	61.8 ± 6.9
L-NAME	13.8 ± 3.6 (8)^***	nd
Diclofenac	84.5 ± 4.6 (7)^**	63.8 ± 5.1
L-NAME + diclof.	11.9 ± 1.8 (5)^***	nd
ODQ	32.7 ± 3.8 (6)^***	78.7 ± 6.3^*
MDL-12,330A	77.8 ± 5.8 (5)^*	62.7 ± 4.8
Atropine	96.7 ± 3.8 (6)	62.8 ± 6.2
Propranolol	98.2 ± 4.9 (6)	58.5 ± 5.9

Number between parentheses indicates the number of animals. Values are means ± S.E.M.
Asterisks compared to group E⁺ (ANOVA followed by Newman-Keuls multiple comparison test, ^*P < 0.05; ^**P < 0.01; ^***P < 0.001 (nd = not determined due to the intense inhibitory effect)).