The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/K_ATP Signaling Pathway

Figure 2

Gastric mucosal lesions: macro- and microscopic aspects. Animals were sacrificed, and their stomachs were opened along the greater curvature. For macroscopic evaluation, images were selected from animals belonging to the corresponding experimental groups (a1–d1). Samples of the gastric mucosa were removed to perform histological analyses (a2–d2). Hematoxylin-eosin stained sections were employed to obtain photomicrographs and to estimate hemorrhage, loss of epithelial cells, and inflammatory infiltrates (arrow) among the different experimental groups: (a1, a2) negative control group, (b1, b2) positive control group, (c1, c2) PrLP 0.5 mg/kg, i.v., and (d1, d2) NAC (200x magnification).