The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/K_ATP Signaling Pathway

Figure 4

Involvement of nitric oxide in ethanol-induced gastric mucosal lesions. Animals were sacrificed, and their stomachs were immediately excised to evaluate the extension of the ulcerated area. Data are expressed as the mean ± standard error mean (SEM) of the number of lesions (8 animals per group), expressed in percent. indicates a significant difference compared with the positive control group (vehicle); indicates a significant difference compared with animals treated only with PrLP; indicates a significant difference compared with animals treated only with L-arginine (ANOVA, Newman-Keuls test).