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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 729017, 8 pages
http://dx.doi.org/10.1155/2015/729017
Research Article

Polydatin Inhibits Formation of Macrophage-Derived Foam Cells

1Department of Cardiovascular Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
2Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
3Qilu Hospital of Shandong University, Jinan 250012, China
4Shandong University of Traditional Chinese Medicine, Shandong 250355, China

Received 1 March 2015; Accepted 4 May 2015

Academic Editor: Dan Hu

Copyright © 2015 Min Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Rhizoma Polygoni Cuspidati, a Chinese herbal medicine, has been widely used in traditional Chinese medicine for a long time. Polydatin, one of the major active ingredients in Rhizoma Polygoni Cuspidati, has been recently shown to possess extensive cardiovascular pharmacological activities. In present study, we examined the effects of Polydatin on the formation of peritoneal macrophage-derived foam cells in Apolipoprotein E gene knockout mice (ApoE−/−) and explored the potential underlying mechanisms. Peritoneal macrophages were collected from ApoE−/− mice and cultured in vitro. These cells sequentially were divided into four groups: Control group, Model group, Lovastatin group, and Polydatin group. Our results demonstrated that Polydatin significantly inhibits the formation of foam cells derived from peritoneal macrophages. Further studies indicated that Polydatin regulates the metabolism of intracellular lipid and possesses anti-inflammatory effects, which may be regulated through the PPAR-γ signaling pathways.