Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein

Table 3

The modulation of CYP and P-gp by green tea.

Compound type	Species	System	CYP	P-gp	Ref.
Extract	Rat	In vivo; Activity	CYP1A (↑); CYP2B (↑); CYP3A (↑)		[41–43]
Extract	Human	In vitro; Activity	CYP2C9 (↓); CYP2D6 (↓); CYP3A4 (↓)		[43]
Extract	Human	In vitro; mRNA/protein	CYP1A1 (↑); CYP1A2 (↑)		[44]
EGCG	Human	In vitro; Activity	CYP1A2 (↓); CYP3A4 (↓)		[44]
Catechins	Human	In vitro; Activity		P-gp (↓)	[45]
EGCG	Human	In vitro; Activity		P-gp (↓)	[46]