Review Article

Advances in the Research and Development of Natural Health Products as Main Stream Cancer Therapeutics

Table 1

Natural health products that target the angiogenesis pathways.

NHPs/NPsTarget (decrease)

Artemisia annua (artemisinin) VEGF/KDR
Camellia sinensis (epigallocatechin)VEGF
protein kinase C
Chrysobalanus icaco (methanol extract)
Curcuma longa (curcumin)MMP-2/9
VEGF
bFGF
CD13 (aminopeptidase N)
Ginkgo biloba (ginkgolide B) VEGF
Magnolia obovata (honokiol)PGDF 
TGF
Polygonum cuspidatum (resveratrol)MMP-2
VEGF
QuercetinCOX-2
lipoxygenase-5 enzymes
EGFR
Scutellaria baicalensis (baicalin and baicalein)VEGF
bFGF
12-lipoxygenase activity
MMP
Silybum marianum (silymarin) VEGF
Viscum album (lectins) VEGF
Squalus acanthias (dogfish liver: squalamine) HER2
Soy isoflavones (genistein, daidzein) EGFR (HER1)
Aloe barbadensis (aloe vera leaf and pulp extracts)HER2/neu
Omega-3 fatty acids (eicosapentaenoic acid, docosahexaenoic acid)COX-2
lipoxygenase-5 enzymes
EGFR
Ocimum sanctum (carnosol, ursolic acid)COX-2
NF-B
several tyrosine kinases
EGFR
Rosmarinus officinalis (carnosol and ursolic acid) COX-2
NF-B
several tyrosine kinases
EGFR
Zingiber officinale (6-gingerol)COX-2
NF-B