Hypocholesterolemic and Antiatherosclerotic Potential of Basella alba Leaf Extract in Hypercholesterolemia-Induced Rabbits

Table 3

Levels of ALT, AST, and CK in serum of rabbits from various groups.

	G1	G2	G3	G4	G5
ALT (U/L)
Baseline	21.22 ± 1.27	20.30 ± 1.47	23.20 ± 1.37	21.43 ± 1.53	22.45 ± 0.75
Week 4	21.05 ± 2.79	43.10 ± 4.67	47.75 ± 1.79	44.85 ± 1.44	46.18 ± 0.51
Week 8	24.62 ± 1.65	63.75 ± 3.48	64.98 ± 6.99	67.85 ± 1.36	69.75 ± 1.48
Week 12	29.15 ± 1.07	91.80 ± 4.45	104.85 ± 4.53	40.35 ± 2.24	38.43 ± 2.28
AST (U/L)
Baseline	29.65 ± 1.23	29.65 ± 4.06	28.18 ± 3.86	25.93 ± 3.15	27.13 ± 4.16
Week 4	32.97 ± 3.78	49.75 ± 8.63	51.78 ± 6.57	47.68 ± 5.57	46.33 ± 1.33
Week 8	36.97 ± 1.09	67.48 ± 8.76	69.30 ± 8.17	67.65 ± 5.64	71.65 ± 2.84
Week 12	39.87 ± 2.37	95.77 ± 8.54	113.75 ± 4.46	42.38 ± 3.46	40.32 ± 4.00
CK (U/L)
Baseline	540.30 ± 22.85	578.80 ± 20.72	556.23 ± 51.60	544.08 ± 35.39	569.30 ± 36.96
Week 4	555.50 ± 25.17	900.48 ± 75.95	886.55 ± 113.73	865.90 ± 88.06	881.45 ± 6.00
Week 8	579.02 ± 22.00	1466.00 ± 233.42	1562.13 ± 196.69	1325.28 ± 97.91	1362.88 ± 104.08
Week 12	597.80 ± 13.49	1931.48 ± 223.55	2093.95 ± 272.50	1004.30 ± 100.27	1051.03 ± 99.88

G1: normal control, G2: hypercholesterolemic control, G3: simvastatin-treated (10 mg/kg), G4: B. alba extract-treated (100 mg/kg), and G5: B. alba extract-treated (200 mg/kg). All data are presented as the mean ± SD ( for each group). One-way ANOVA was performed followed by Dunnett’s post hoc test for multiple comparisons. Within a week, values sharing the same superscript letters are not significantly different from each other ( < 0.05).