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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 760539, 7 pages
http://dx.doi.org/10.1155/2015/760539
Research Article

A Glucosamine-Specific Lectin from Green Dragon No. 8 Beans (Phaseolus vulgaris) Induced Apoptosis on Nasopharyngeal Carcinoma Cells

1State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, School of Medicine, Shenzhen University, Nanhai Avenue 3688, Shenzhen, Guangdong 518060, China
2Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, School of Medicine, Shenzhen University, Nanhai Avenue 3688, Shenzhen, Guangdong 518060, China
3School of Biomedical Sciences, The Chinese University of Hong Kong, Lo Kwee Seong Integrated Biomedical Sciences Building, Shatin, New Territories, Hong Kong

Received 12 March 2015; Revised 6 July 2015; Accepted 7 July 2015

Academic Editor: Nunziatina De Tommasi

Copyright © 2015 Yau Sang Chan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Bouchenak and M. Lamri-Senhadji, “Nutritional quality of legumes, and their role in cardiometabolic risk prevention: a review,” Journal of Medicinal Food, vol. 16, no. 3, pp. 185–198, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. U. Singh, “Antinutritional factors of chickpea and pigeonpea and their removal by processing,” Plant Foods for Human Nutrition, vol. 38, no. 3, pp. 251–261, 1988. View at Publisher · View at Google Scholar · View at Scopus
  3. E. O. Mello, S. F. F. Ribeiro, A. O. Carvalho et al., “Antifungal activity of PvD1 defensin involves plasma membrane permeabilization, inhibition of medium acidification, and induction of ROS in fungi cells,” Current Microbiology, vol. 62, no. 4, pp. 1209–1217, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. V. D. S. Ramos, O. G. Cabrera, E. L. O. Camargo et al., “Molecular cloning and insecticidal effect of Inga laurina trypsin inhibitor on Diatraea saccharalis and Heliothis virescens,” Comparative Biochemistry and Physiology—C Toxicology and Pharmacology, vol. 156, no. 3-4, pp. 148–158, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. W.-T. Kuo, Y.-J. Ho, S.-M. Kuo et al., “Induction of the mitochondria apoptosis pathway by phytohemagglutinin erythroagglutinating in human lung cancer cells,” Annals of Surgical Oncology, vol. 18, no. 3, pp. 848–856, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Alizadeh, D. W. M. Leung, and A. L. J. Cole, “Conidiogenic effects of mannose-binding lectins isolated from cotyledons of red kidney bean (Phaseolus vulgaris) on Alternaria alternata,” Phytochemistry, vol. 72, no. 1, pp. 94–99, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Z. Castellanos, H. Guzman-Maldonado, E. G. de Mejia, and J. A. Acosta-Gallegos, “Effect of growing location on sensory properties and nutritional characteristics of black beans (Phaseolus vulgaris L.),” Archivos latinoamericanos de nutrición, vol. 45, no. 1, pp. 50–55, 1995. View at Google Scholar · View at Scopus
  8. T. C. Osborn, J. W. S. Brown, and F. A. Bliss, “Bean lectins: 5. Quantitative genetic variation in seed lectins of Phaseolus vulgaris L. and its relationship to qualitative lectin variation,” Theoretical and Applied Genetics, vol. 70, no. 1, pp. 22–31, 1985. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. S. Chan, J. H. Wong, E. F. Fang, W. Pan, and T. B. Ng, “Isolation of a glucosamine binding leguminous lectin with mitogenic activity towards splenocytes and anti-proliferative activity towards tumor cells,” PLoS ONE, vol. 7, no. 6, Article ID e38961, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Sharma, J. H. Wong, P. Lin, Y. S. Chan, and T. B. Ng, “Purification and characterization of a lectin from the Indian cultivar of French bean seeds,” Protein and Peptide Letters, vol. 17, no. 2, pp. 221–227, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Lin, X. Ye, and T. Ng, “Purification of melibiose-binding lectins from two cultivars of Chinese black soybeans,” Acta Biochimica et Biophysica Sinica, vol. 40, no. 12, pp. 1029–1038, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. S. X. Wang, G. Q. Zhang, S. Zhao et al., “Purification and characterization of a novel lectin with antiphytovirus activities from the wild mushroom Paxillus involutus,” Protein and Peptide Letters, vol. 20, no. 7, pp. 767–774, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Khan, A. Ahmad, and M. I. Khan, “Purification and characterization of a lectin from endophytic fungus Fusarium solani having complex sugar specificity,” Archives of Biochemistry and Biophysics, vol. 457, no. 2, pp. 243–251, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. R. C. F. Cheung, H. H. Leung, W. L. Pan, and T. B. Ng, “A calcium ion-dependent dimeric bean lectin with antiproliferative activity toward human breast cancer MCF-7 Cells,” Protein Journal, vol. 32, no. 3, pp. 208–215, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Z. Zhang, E. F. Fang, H.-T. Zhang, L.-L. Liu, and J.-P. Yun, “Momordica Charantia lectin exhibits antitumor activity towards hepatocellular carcinoma,” Investigational New Drugs, vol. 33, no. 1, article 156, pp. 1–11, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Rafiq, R. Majeed, A. K. Qazi et al., “Isolation and antiproliferative activity of Lotus corniculatus lectin towards human tumour cell lines,” Phytomedicine, vol. 21, no. 1, pp. 30–38, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. A. S. W. Ang, R. C. F. Cheung, X. Dan, Y. S. Chan, W. Pan, and T. B. Ng, “Purification and characterization of a glucosamine-binding antifungal lectin from Phaseolus vulgaris cv. Chinese Pinto Beans with antiproliferative activity towards nasopharyngeal carcinoma cells,” Applied Biochemistry and Biotechnology, vol. 172, no. 2, pp. 672–686, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. E. F. Fang, W. L. Pan, J. H. Wong, Y. S. Chan, X. J. Ye, and T. B. Ng, “A new Phaseolus vulgaris lectin induces selective toxicity on human liver carcinoma Hep G2 cells,” Archives of Toxicology, vol. 85, no. 12, pp. 1551–1563, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Bardocz, G. Grant, S. W. B. Ewen et al., “Reversible effect of phytohaemagglutinin on the growth and metabolism of rat gastrointestinal tract,” Gut, vol. 37, no. 3, pp. 353–360, 1995. View at Publisher · View at Google Scholar · View at Scopus
  20. R. N. Chopra, I. C. Chopra, K. I. Handa, and L. D. Kapur, “Medicinal plants in diabetes,” in Indigenous Drugs of India, pp. 314–316, Academic Publishers, 2nd edition, 1958. View at Google Scholar
  21. B. Longo-Mbenza and M. Muaka, “The protective effect of Phaseolus vulgaris on cataract in type 2 diabetes: a profitable hypothesis,” Medical Hypothesis, Discovery & Innovation Ophthalmology, vol. 2, no. 4, pp. 105–108, 2013. View at Google Scholar
  22. I. Onakpoya, S. Aldaas, R. Terry, and E. Ernst, “The efficacy of Phaseolus vulgaris as a weight-loss supplement: a systematic review and meta-analysis of randomised clinical trials,” British Journal of Nutrition, vol. 106, no. 2, pp. 196–202, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. M. A. Tormo, I. Gil-Exojo, A. R. Romero de Tejada, and J. E. Campillo, “Hypoglycaemic and anorexigenic activities of an α-amylase inhibitor from white kidney beans (Phaseolus vulgaris) in Wistar rats,” British Journal of Nutrition, vol. 92, no. 5, pp. 785–790, 2004. View at Publisher · View at Google Scholar · View at Scopus