Rapid Antidepressant Activity of Ethanol Extract of <i>Gardenia jasminoides</i> Ellis Is Associated with Upregulation of BDNF Expression in the Hippocampus

<div>Identification of the herb primary for rapid antidepressant effect of Yueju at 24 hours after a single administration. Immobility time was measured for the last 4 minutes during the 6-minute testing time of TST. (a) Effects of individual constituent herbs of Yueju at 0.8 g/kg. Groups: Con. (control), GJ, AL, LC, MF, and CR. One-way analysis of variance (ANOVA),<i> F</i><sub>(5,59)</sub> = 2.58, <svg height="9.65971pt" id="M9" style="vertical-align:-0.6617603pt" version="1.1" viewbox="-0.0498162 -8.99795 46.7259 9.65971" width="46.7259pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="617" vert-adv-y="617"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,12.15,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z" id="g117-91"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" 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horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg> versus control (LSD post hoc tests). (b) Dose-effect relationship of GJ. ANOVA,<i> F</i><sub>(3,47)</sub> = 5.97, <svg height="9.65971pt" id="M12" style="vertical-align:-0.6617603pt" version="1.1" viewbox="-0.0498162 -8.99795 46.7259 9.65971" width="46.7259pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="617" vert-adv-y="617"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,12.15,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z" id="g117-91"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="587" 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id="g113-50"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="480" vert-adv-y="480"></glyph.data></g></svg> versus control (LSD post hoc tests).</div>

Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: Rapid Antidepressant Activity of Ethanol Extract of <i>Gardenia jasminoides</i> Ellis Is Associated with Upregulation of BDNF Expression in the Hippocampus 

Figure 2 | Rapid Antidepressant Activity of Ethanol Extract of Gardenia jasminoides Ellis Is Associated with Upregulation of BDNF Expression in the Hippocampus 